Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction

Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pregnancy 2017-01, Vol.2017 (2017), p.1-5
Main Authors: Georgiou, Harry M., Brennecke, Shaun Patrick, Kalionis, Bill, Yong, Hannah E. J., Chollangi, Tejasvy, Wookey, Alice F., Murthi, Padma
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Chi-Square Distribution
Diabetes
Enzyme-Linked Immunosorbent Assay
Female
Fetal Development
Fetal Growth Retardation - metabolism
Health risk assessment
Humans
Hypertension
Inflammation
Metabolism
Metabolites
Obstetrics
Placenta
Placenta - metabolism
Preeclampsia
Pregnancy
Proteins
Studies
Vitamin D
Vitamin D-Binding Protein - metabolism
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3
cites cdi_FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3
container_end_page 5
container_issue 2017
container_start_page 1
container_title Journal of pregnancy
container_volume 2017
creator Georgiou, Harry M.
Brennecke, Shaun Patrick
Kalionis, Bill
Yong, Hannah E. J.
Chollangi, Tejasvy
Wookey, Alice F.
Murthi, Padma
description Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p
doi_str_mv 10.1155/2017/5120267
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_431e4403347f493cae8e34fe08a919de</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_431e4403347f493cae8e34fe08a919de</doaj_id><sourcerecordid>4317496051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhi0EotXSG2cUiQsShNoeJ3YuSFD6sVIlKgRcOFgTx9n1Kom3dkLh3-Owy0I54Yvtmcevxu8MIU8Zfc1YUZxyyuRpwTjlpXxAjjmtaM4lFA8PZy6PyEmMG5qWUIwy_pgcccUrEFAek683HRo7jNhlX9yIvRuy9_k7NzRuWGU3wY82Rc6_b4ON0fkhS7erqcchWzbOb3FcO5Nd2Pn5ZfB34zr7aOMYnBkT_IQ8arGL9mS_L8jni_NPZ1f59YfL5dnb69wUIMcci0pBC1SWYGtVStqUhiNvDJi2VK3kIEXJKy6Ri7quEymYScmSIdRQIyzIcqfbeNzobXA9hh_ao9O_Aj6sNIbRmc5qAcwKQQGEbEUFBq2yIFpLFVasamzSerPT2k51b5vZmoDdPdH7mcGt9cp_0wUA45VMAi_2AsHfTskM3btobNfhYP0UNVNSqgIKphL6_B9046cwJKtmihdKsFTpgrzaUSb4GINtD8Uwquch0PMQ6P0QJPzZ3x84wL9bnoCXO2Cduox37j_lbGJsi39opkoqAX4Ca9XCUw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1872584103</pqid></control><display><type>article</type><title>Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction</title><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Georgiou, Harry M. ; Brennecke, Shaun Patrick ; Kalionis, Bill ; Yong, Hannah E. J. ; Chollangi, Tejasvy ; Wookey, Alice F. ; Murthi, Padma</creator><contributor>Wing, Deborah A.</contributor><creatorcontrib>Georgiou, Harry M. ; Brennecke, Shaun Patrick ; Kalionis, Bill ; Yong, Hannah E. J. ; Chollangi, Tejasvy ; Wookey, Alice F. ; Murthi, Padma ; Wing, Deborah A.</creatorcontrib><description>Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p&lt;0.05, Student’s t-test) that were strongly associated with idiopathic fetal growth restriction (p&lt;0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p=0.295, Pearson’s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.</description><identifier>ISSN: 2090-2727</identifier><identifier>EISSN: 2090-2735</identifier><identifier>DOI: 10.1155/2017/5120267</identifier><identifier>PMID: 28293436</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Biomarkers - blood ; Case-Control Studies ; Chi-Square Distribution ; Diabetes ; Enzyme-Linked Immunosorbent Assay ; Female ; Fetal Development ; Fetal Growth Retardation - metabolism ; Health risk assessment ; Humans ; Hypertension ; Inflammation ; Metabolism ; Metabolites ; Obstetrics ; Placenta ; Placenta - metabolism ; Preeclampsia ; Pregnancy ; Proteins ; Studies ; Vitamin D ; Vitamin D-Binding Protein - metabolism ; Womens health</subject><ispartof>Journal of pregnancy, 2017-01, Vol.2017 (2017), p.1-5</ispartof><rights>Copyright © 2017 Alice F. Wookey et al.</rights><rights>Copyright © 2017 Alice F. Wookey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Alice F. Wookey et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3</citedby><cites>FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3</cites><orcidid>0000-0003-3070-6971 ; 0000-0003-2535-5134 ; 0000-0003-0553-9489 ; 0000-0002-0132-9858</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1872584103/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1872584103?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28293436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wing, Deborah A.</contributor><creatorcontrib>Georgiou, Harry M.</creatorcontrib><creatorcontrib>Brennecke, Shaun Patrick</creatorcontrib><creatorcontrib>Kalionis, Bill</creatorcontrib><creatorcontrib>Yong, Hannah E. J.</creatorcontrib><creatorcontrib>Chollangi, Tejasvy</creatorcontrib><creatorcontrib>Wookey, Alice F.</creatorcontrib><creatorcontrib>Murthi, Padma</creatorcontrib><title>Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction</title><title>Journal of pregnancy</title><addtitle>J Pregnancy</addtitle><description>Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p&lt;0.05, Student’s t-test) that were strongly associated with idiopathic fetal growth restriction (p&lt;0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p=0.295, Pearson’s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Diabetes</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fetal Development</subject><subject>Fetal Growth Retardation - metabolism</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Obstetrics</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Studies</subject><subject>Vitamin D</subject><subject>Vitamin D-Binding Protein - metabolism</subject><subject>Womens health</subject><issn>2090-2727</issn><issn>2090-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhi0EotXSG2cUiQsShNoeJ3YuSFD6sVIlKgRcOFgTx9n1Kom3dkLh3-Owy0I54Yvtmcevxu8MIU8Zfc1YUZxyyuRpwTjlpXxAjjmtaM4lFA8PZy6PyEmMG5qWUIwy_pgcccUrEFAek683HRo7jNhlX9yIvRuy9_k7NzRuWGU3wY82Rc6_b4ON0fkhS7erqcchWzbOb3FcO5Nd2Pn5ZfB34zr7aOMYnBkT_IQ8arGL9mS_L8jni_NPZ1f59YfL5dnb69wUIMcci0pBC1SWYGtVStqUhiNvDJi2VK3kIEXJKy6Ri7quEymYScmSIdRQIyzIcqfbeNzobXA9hh_ao9O_Aj6sNIbRmc5qAcwKQQGEbEUFBq2yIFpLFVasamzSerPT2k51b5vZmoDdPdH7mcGt9cp_0wUA45VMAi_2AsHfTskM3btobNfhYP0UNVNSqgIKphL6_B9046cwJKtmihdKsFTpgrzaUSb4GINtD8Uwquch0PMQ6P0QJPzZ3x84wL9bnoCXO2Cduox37j_lbGJsi39opkoqAX4Ca9XCUw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Georgiou, Harry M.</creator><creator>Brennecke, Shaun Patrick</creator><creator>Kalionis, Bill</creator><creator>Yong, Hannah E. J.</creator><creator>Chollangi, Tejasvy</creator><creator>Wookey, Alice F.</creator><creator>Murthi, Padma</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7R6</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>888</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQGEN</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>QXPDG</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3070-6971</orcidid><orcidid>https://orcid.org/0000-0003-2535-5134</orcidid><orcidid>https://orcid.org/0000-0003-0553-9489</orcidid><orcidid>https://orcid.org/0000-0002-0132-9858</orcidid></search><sort><creationdate>20170101</creationdate><title>Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction</title><author>Georgiou, Harry M. ; Brennecke, Shaun Patrick ; Kalionis, Bill ; Yong, Hannah E. J. ; Chollangi, Tejasvy ; Wookey, Alice F. ; Murthi, Padma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Diabetes</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fetal Development</topic><topic>Fetal Growth Retardation - metabolism</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Obstetrics</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Studies</topic><topic>Vitamin D</topic><topic>Vitamin D-Binding Protein - metabolism</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georgiou, Harry M.</creatorcontrib><creatorcontrib>Brennecke, Shaun Patrick</creatorcontrib><creatorcontrib>Kalionis, Bill</creatorcontrib><creatorcontrib>Yong, Hannah E. J.</creatorcontrib><creatorcontrib>Chollangi, Tejasvy</creatorcontrib><creatorcontrib>Wookey, Alice F.</creatorcontrib><creatorcontrib>Murthi, Padma</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>GenderWatch (ProQuest)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>GenderWatch (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest Women's &amp; Gender Studies</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Diversity Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Journal of pregnancy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georgiou, Harry M.</au><au>Brennecke, Shaun Patrick</au><au>Kalionis, Bill</au><au>Yong, Hannah E. J.</au><au>Chollangi, Tejasvy</au><au>Wookey, Alice F.</au><au>Murthi, Padma</au><au>Wing, Deborah A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction</atitle><jtitle>Journal of pregnancy</jtitle><addtitle>J Pregnancy</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>2090-2727</issn><eissn>2090-2735</eissn><abstract>Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p&lt;0.05, Student’s t-test) that were strongly associated with idiopathic fetal growth restriction (p&lt;0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p=0.295, Pearson’s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28293436</pmid><doi>10.1155/2017/5120267</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3070-6971</orcidid><orcidid>https://orcid.org/0000-0003-2535-5134</orcidid><orcidid>https://orcid.org/0000-0003-0553-9489</orcidid><orcidid>https://orcid.org/0000-0002-0132-9858</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-2727
ispartof Journal of pregnancy, 2017-01, Vol.2017 (2017), p.1-5
issn 2090-2727
2090-2735
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_431e4403347f493cae8e34fe08a919de
source Wiley-Blackwell Open Access Collection; Publicly Available Content Database; PubMed Central
subjects Adult
Biomarkers - blood
Case-Control Studies
Chi-Square Distribution
Diabetes
Enzyme-Linked Immunosorbent Assay
Female
Fetal Development
Fetal Growth Retardation - metabolism
Health risk assessment
Humans
Hypertension
Inflammation
Metabolism
Metabolites
Obstetrics
Placenta
Placenta - metabolism
Preeclampsia
Pregnancy
Proteins
Studies
Vitamin D
Vitamin D-Binding Protein - metabolism
Womens health
title Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A03%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Placental%20Vitamin%20D-Binding%20Protein%20Expression%20in%20Human%20Idiopathic%20Fetal%20Growth%20Restriction&rft.jtitle=Journal%20of%20pregnancy&rft.au=Georgiou,%20Harry%20M.&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=5&rft.pages=1-5&rft.issn=2090-2727&rft.eissn=2090-2735&rft_id=info:doi/10.1155/2017/5120267&rft_dat=%3Cproquest_doaj_%3E4317496051%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c537t-a5983f30763eb8670d6c2a2dc3cf68f7237462927a24bbbf3041cc3c61a3b3ba3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1872584103&rft_id=info:pmid/28293436&rfr_iscdi=true