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Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population
The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorec...
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| Published in: | Scientific reports 2017-03, Vol.7 (1), p.128-8, Article 128 |
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| creator | Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon |
| description | The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether
CYP1A1
genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore,
CYP1A1
genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the
CYP1A1
rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (
P
for interaction = 0.02), particularly for rectal cancer (
P
for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and
CYP1A1
genetic variants. |
| doi_str_mv | 10.1038/s41598-017-00117-8 |
| format | article |
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CYP1A1
genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore,
CYP1A1
genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the
CYP1A1
rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (
P
for interaction = 0.02), particularly for rectal cancer (
P
for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and
CYP1A1
genetic variants.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-00117-8</identifier><identifier>PMID: 28273931</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/23 ; 631/67/2195 ; 631/67/2324 ; Asian Continental Ancestry Group - genetics ; Colorectal Neoplasms - genetics ; Cytochrome P-450 CYP1A1 - genetics ; Diet ; Female ; Flavonoids - adverse effects ; Flavonoids - metabolism ; Genetic Predisposition to Disease ; Humanities and Social Sciences ; Humans ; Male ; Middle Aged ; multidisciplinary ; Polymorphism, Single Nucleotide ; Republic of Korea ; Science ; Science (multidisciplinary) ; Surveys and Questionnaires</subject><ispartof>Scientific reports, 2017-03, Vol.7 (1), p.128-8, Article 128</ispartof><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-8d70afeda94cfc5f44753dacc14fe16103c47717d689b72406a2681714ea4c2f3</citedby><cites>FETCH-LOGICAL-c512t-8d70afeda94cfc5f44753dacc14fe16103c47717d689b72406a2681714ea4c2f3</cites><orcidid>0000-0003-3296-6646</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427897/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427897/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28273931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Young Ae</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Oh, Jae Hwan</creatorcontrib><creatorcontrib>Chang, Hee Jin</creatorcontrib><creatorcontrib>Sohn, Dae Kyung</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><title>Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether
CYP1A1
genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore,
CYP1A1
genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the
CYP1A1
rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (
P
for interaction = 0.02), particularly for rectal cancer (
P
for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and
CYP1A1
genetic variants.</description><subject>45/23</subject><subject>631/67/2195</subject><subject>631/67/2324</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Diet</subject><subject>Female</subject><subject>Flavonoids - adverse effects</subject><subject>Flavonoids - metabolism</subject><subject>Genetic Predisposition to Disease</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Republic of Korea</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Surveys and Questionnaires</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kd9qFTEQxoMottS-gBeSB3BtJsmeZG-EsvYfFhRRwaswJ5k9zXGbHLJ7Cr69saulvTEXSZiZ7xe-fIy9BvEOhLInk4a2s40A0wgBdbfP2KEUum2kkvL5o_sBO56mrairlZ2G7iU7kFYa1Sk4ZPQh0ozlFz8f8S6nHMP0lvc_PsMp8AtKNEfPv2OJmObawBT4fEP8S5x-8jzwPo-5kJ9x5D0mT4XHxJF_rEVMfJd3-xHnmNMr9mLAcaLjv-cR-3Z-9rW_bK4_XVz1p9eNb0HOjQ1G4EABO-0H3w5am1YF9B70QLCqvr02BkxY2W5tpBYrlCsLBjSh9nJQR-xq4YaMW7cr8bZacxmjuy_ksnFYqqWRnFYKBSASCNBSrK2QQa7Ba0SlrKDKer-wdvv1LQVPaS44PoE-7aR44zb5zrVaGtuZCpALwJc8TYWGBy0I9ydDt2ToaobuPkNnq-jN41cfJP8SqwNqGZhqK22ouG3el1R_9X_Y31UCpt8</recordid><startdate>20170309</startdate><enddate>20170309</enddate><creator>Cho, Young Ae</creator><creator>Lee, Jeonghee</creator><creator>Oh, Jae Hwan</creator><creator>Chang, Hee Jin</creator><creator>Sohn, Dae Kyung</creator><creator>Shin, Aesun</creator><creator>Kim, Jeongseon</creator><general>Nature Publishing Group UK</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3296-6646</orcidid></search><sort><creationdate>20170309</creationdate><title>Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population</title><author>Cho, Young Ae ; Lee, Jeonghee ; Oh, Jae Hwan ; Chang, Hee Jin ; Sohn, Dae Kyung ; Shin, Aesun ; Kim, Jeongseon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-8d70afeda94cfc5f44753dacc14fe16103c47717d689b72406a2681714ea4c2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>45/23</topic><topic>631/67/2195</topic><topic>631/67/2324</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Diet</topic><topic>Female</topic><topic>Flavonoids - adverse effects</topic><topic>Flavonoids - metabolism</topic><topic>Genetic Predisposition to Disease</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Republic of Korea</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Young Ae</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Oh, Jae Hwan</creatorcontrib><creatorcontrib>Chang, Hee Jin</creatorcontrib><creatorcontrib>Sohn, Dae Kyung</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Young Ae</au><au>Lee, Jeonghee</au><au>Oh, Jae Hwan</au><au>Chang, Hee Jin</au><au>Sohn, Dae Kyung</au><au>Shin, Aesun</au><au>Kim, Jeongseon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-03-09</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>128</spage><epage>8</epage><pages>128-8</pages><artnum>128</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether
CYP1A1
genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore,
CYP1A1
genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the
CYP1A1
rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (
P
for interaction = 0.02), particularly for rectal cancer (
P
for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and
CYP1A1
genetic variants.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28273931</pmid><doi>10.1038/s41598-017-00117-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3296-6646</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2017-03, Vol.7 (1), p.128-8, Article 128 |
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| source | Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 45/23 631/67/2195 631/67/2324 Asian Continental Ancestry Group - genetics Colorectal Neoplasms - genetics Cytochrome P-450 CYP1A1 - genetics Diet Female Flavonoids - adverse effects Flavonoids - metabolism Genetic Predisposition to Disease Humanities and Social Sciences Humans Male Middle Aged multidisciplinary Polymorphism, Single Nucleotide Republic of Korea Science Science (multidisciplinary) Surveys and Questionnaires |
| title | Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population |
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