Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers' water-resistant ability for potential biomedical applications, the electrospun...

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Bibliographic Details
Published in:Pharmaceutics 2019-09, Vol.11 (9), p.449
Main Authors: Han, Xinxu, Huo, Peipei, Ding, Zhongfeng, Kumar, Parveen, Liu, Bo
Format: Article
Language:English
Subjects:
Acids
Aluminum
Aqueous solutions
Bioavailability
Biocompatibility
Contact angle
Drug delivery systems
Drugs
Efficiency
Fourier transforms
Hydrogen bonds
Investigations
lutein
Mechanical properties
Morphology
nanofibers
Polymers
Polyvinyl alcohol
Potassium
Sodium
sodium alginate
Spectrum analysis
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Summary:This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers' water-resistant ability for potential biomedical applications, the electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and saturated boric acid solution at room temperature. The nanofibers were characterized using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle measurements testified the hydrophilicity change of the nanofibers before and after cross-linking. The lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption spectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian) release mechanism as indicated by diffusion exponent value obtained from the Korsmeyer-Peppas equation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great potential as a controlled release system.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics11090449