Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

Delayed cerebral ischemia (DCI) is a life-threatening complication after subarachnoid hemorrhage. There is a strong association between cerebral vessel narrowing and DCI. Alpha calcitonin gene-related peptide (αCGRP) is a potent vasodilator, which may be effective at reducing cerebral vessel narrowi...

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Bibliographic Details
Published in:Frontiers in neurology 2017-07, Vol.8, p.357-357
Main Authors: Flynn, Liam M C, Begg, Caroline J, Macleod, Malcolm R, Andrews, Peter J D
Format: Article
Language:English
Subjects:
calcitonin gene-related peptide
cerebral vasospasm
CGRP
delayed cerebral ischemia
Neuroscience
subarachnoid hemorrhage
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Summary:Delayed cerebral ischemia (DCI) is a life-threatening complication after subarachnoid hemorrhage. There is a strong association between cerebral vessel narrowing and DCI. Alpha calcitonin gene-related peptide (αCGRP) is a potent vasodilator, which may be effective at reducing cerebral vessel narrowing after subarachnoid hemorrhage (SAH). Here, we report a meta-analysis of data from nine animal studies identified in a systematic review in which αCGRP was administered in SAH models. Our primary outcome was change in cerebral vessel diameter and the secondary outcome was change in neurobehavioral scores. There was a 40.8 ± 8.2% increase in cerebral vessel diameter in those animals treated with αCGRP compared with controls (  
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2017.00357