Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus

With people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from the interaction of genetic and various environmental factors. Among all the T2DM related...

Full description

Saved in:
Bibliographic Details
Published in:Biotechnology, biotechnological equipment biotechnological equipment, 2018-07, Vol.32 (4), p.830-834
Main Authors: Huang, Zhi-qiu, Liao, Yao-qi, Huang, Run-ze, Chen, Jin-peng, Sun, Hui-lin
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Environmental factors
Genes
genetic mutation
Metabolic disorders
Pathogenesis
proinsulin conversion
T2DM
TCF7L2
Wnt signaling pathway
β-cell apoptosis
β-cell responsiveness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:With people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from the interaction of genetic and various environmental factors. Among all the T2DM related genes, the transcription factor 7 like 2 (TCF7L2) gene is one of the most relevant risk-related genes for T2DM. However, the role of TCF7L2 in T2DM pathogenesis has not yet been interpreted thoroughly. Based on the experimental studies in recent years, this review discusses several possible mechanisms of T2DM pathogenesis induced by TCF7L2.
ISSN:1310-2818
1314-3530
DOI:10.1080/13102818.2018.1438211