Synergistic activity between Triphala and selected antibiotics against drug resistant clinical isolates

Triphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug resistant organisms. The checkerboard method was used to determine the synergy of Triphala wi...

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Bibliographic Details
Published in:BMC complementary and alternative medicine 2019-08, Vol.19 (1), p.199-199, Article 199
Main Authors: Manoraj, Amirthasingam, Thevanesam, Vasanthi, Bandara, B M R, Ekanayake, Asela, Liyanapathirana, Veranja
Format: Article
Language:English
Subjects:
Aminoglycosides
Anti-Bacterial Agents - pharmacology
Backup software
Care and treatment
Drug resistance
Drug Resistance, Bacterial
Drug Synergism
Gentamicin
Gentamicins - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Gram-Negative Bacterial Infections - microbiology
Health aspects
Humans
MDR gram negatives
Medical research
Medical supplies
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
MRSA
Oxacillin
Oxacillin - pharmacology
Plant Extracts - pharmacology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus infections
Synergy
Triphala
Wounds
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Summary:Triphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug resistant organisms. The checkerboard method was used to determine the synergy of Triphala with gentamicin and oxacillin against multi-drug resistant (MDR) Gram negative bacilli and methicillin-resistant Staphylococcus aureus (MRSA) using 2,3,5-triphenyltetrazolium chloride (TTC) assay. Fractional inhibitory concentration (FIC) index was calculated. When tested alone, the minimum inhibitory concentration (MIC) values of gentamicin for Gram negative isolates ranged from 8 to > 64 μg/ml. The MIC values of gentamicin for the Gram negative isolates ranged from 1 to 32 μg/ml when tested with Triphala. The FIC index was  16 μg/ml with all MICs being equal to or higher than the resistance cut-off level. The MIC level with the addition of Triphala ranged from 0.25 to 4 μg/ml. FIC index was
ISSN:1472-6882
1472-6882
DOI:10.1186/s12906-019-2618-1