Improving the Efficacy of Magnetic Nanoparticle-Mediated Hyperthermia Using Trapezoidal Pulsed Electromagnetic Fields as an In Vitro Anticancer Treatment in Melanoma and Glioblastoma Multiforme Cell Lines

Magnetic hyperthermia (MHT) is an oncological therapy that uses magnetic nanoparticles (MNPs) to generate localized heat under a low-frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMFs) have proven their efficacy in enhancing the efficiency of...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-11, Vol.24 (21), p.15933
Main Authors: Souiade, Lilia, Domingo-Diez, Javier, Alcaide, Cesar, Gámez, Berta, Gámez, Linarejos, Ramos, Milagros, Serrano Olmedo, José Javier
Format: Article
Language:English
Subjects:
alternating magnetic field
Brain cancer
Cancer
Cancer therapies
Care and treatment
Cell death
Cells
Chemotherapy
Comparative analysis
Drug therapy
Efficiency
Electromagnetism
Fever
Gliomas
Heat
Hyperthermia
Magnetic fields
magnetic nanoparticles
Melanoma
Microscopy
Nanoparticles
nonharmonic signals
Radiation
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Summary:Magnetic hyperthermia (MHT) is an oncological therapy that uses magnetic nanoparticles (MNPs) to generate localized heat under a low-frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMFs) have proven their efficacy in enhancing the efficiency of heating in MHT as compared to the sinusoidal one. Our study aims to compare the TPAMF waveform’s killing effect against the sinusoidal waveform in B16F10 and CT2A cell lines to determine more efficient waveforms in causing cell death. For that purpose, we used MNPs and different AMF waveforms: trapezoidal (TP), almost-square (TS), triangular (TR), and sinusoidal signal (SN). MNPs at 1 and 4 mg/mL did not affect cell viability during treatment. The exposition of B16F10 and CT2A cells to only AMF showed nonsignificant mortality. Hence, the synergetic effect of the AMF and MNPs causes the observed cell death. Among the explored cases, the nonharmonic signals demonstrated better efficacy than the SN one as an MHT treatment. This study has revealed that the application of TP, TS, or TR waveforms is more efficient and has considerable capability to increase cancer cell death compared to the traditional sinusoidal treatment. Overall, we can conclude that the application of nonharmonic signals enhances MHT treatment efficiency against tumor cells.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242115933