Nationwide participation in FIT-based colorectal cancer screening in Denmark during the COVID-19 pandemic: An observational study

• Published in: eLife 2023-01, Vol.12
• Main Authors: Olesen, Tina Bech, Jensen, Henry, Møller, Henrik, Jensen, Jens Winther, Andersen, Berit, Rasmussen, Morten
• Format: Article
• Language: English
• Subjects: Aged; Cancer; Cancer screening; Cohabitation; Colonoscopy; Colorectal cancer; colorectal cancer screening; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - epidemiology; Communicable Disease Control; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 diagnostic tests; COVID-19 pandemic; COVID-19 vaccines; Denmark - epidemiology; Disposable income; Early Detection of Cancer; Education; epidemiology; Epidemiology and Global Health; Ethnicity; Humans; Immigrants; Immunization; Mass Screening; Medical screening; Middle Aged; Observational studies; Pandemics; Pandemics - prevention & control; Participation; Society
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.81808

Worldwide, most colorectal cancer screening programmes were paused at the start of the COVID-19 pandemic, while the Danish faecal immunochemical test (FIT)-based programme continued without pausing. We examined colorectal cancer screening participation and compliance with subsequent colonoscopy in Denmark throughout the pandemic. We used data from the Danish Colorectal Cancer Screening Database among individuals aged 50-74 years old invited to participate in colorectal cancer screening from 2018 to 2021 combined with population-wide registries. Using a generalised linear model, we estimated prevalence ratios (PRs) and 95% confidence intervals (CIs) of colorectal cancer screening participation within 90 days since invitation and compliance with colonoscopy within 60 days since a positive FIT test during the pandemic in comparison with the previous years adjusting for age, month and year of invitation. Altogether, 3,133,947 invitations were sent out to 1,928,725 individuals and there were 94,373 positive FIT tests (in 92,848 individuals) during the study period. Before the pandemic, 60.7% participated in screening within 90 days. A minor reduction in participation was observed at the start of the pandemic (PR = 0.95; 95% CI: 0.94-0.96 in pre-lockdown and PR = 0.85; 95% CI: 0.85-0.86 in first lockdown) corresponding to a participation rate of 54.9% during pre-lockdown and 53.0% during first lockdown. This was followed by a 5-10% increased participation in screening corresponding to a participation rate of up to 64.9%. The largest increase in participation was observed among 55-59 years old and among immigrants. The compliance with colonoscopy within 60 days was 89.9% before the pandemic. A slight reduction was observed during first lockdown (PR = 0.96; 95% CI: 0.93-0.98), where after it resumed to normal levels. Participation in the Danish FIT-based colorectal cancer screening programme and subsequent compliance to colonoscopy after a positive FIT result was only slightly affected by the COVID-19 pandemic. The study was funded by the Danish Cancer Society Scientific Committee (Grant number R321-A17417) and the Danish regions.