Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a compre...

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Bibliographic Details
Published in:Hereditas 2020-08, Vol.157 (1), p.33-33, Article 33
Main Authors: Shen, Wenhao, Xiao, Li, Li, Yang, Zhou, Daming, Zhang, Wei
Format: Article
Language:English
Subjects:
Genes
Genotype & phenotype
Immune response
Innate immunity
Lectins
Mannose
Mannose-binding lectin
Meta-analysis
Mutation
Polymorphism
Pulmonary tuberculosis
Single-nucleotide polymorphism
Susceptibility
Tuberculosis
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Summary:Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships. There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891. Our current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.
ISSN:1601-5223
0018-0661
1601-5223
DOI:10.1186/s41065-020-00146-w