Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells

Peptides are secreted by different cell types and are trendy therapeutic agents that have attracted attention for the treatment of several diseases such as infections. Antimicrobial peptides exert various mechanisms such as changing cell membrane permeability which leads to inhibition or death of ba...

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Bibliographic Details
Published in:Heliyon 2019-10, Vol.5 (10), p.e02652, Article e02652
Main Authors: Esfandiyari, Reza, Halabian, Raheleh, Behzadi, Elham, Sedighian, Hamid, Jafari, Ramezan, Imani Fooladi, Abbas Ali
Format: Article
Language:English
Subjects:
Antimicrobial peptides
Bacteria
Biotechnology
Infectious disease
Mesenchymal stem cells
Microbiology
Molecular biology
Proteins
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Summary:Peptides are secreted by different cell types and are trendy therapeutic agents that have attracted attention for the treatment of several diseases such as infections. Antimicrobial peptides exert various mechanisms such as changing cell membrane permeability which leads to inhibition or death of bacterial cells. mesenchymal stem cells (MSCs) are key to produce antimicrobial peptides and to inhibit the growth of pathogens. These cells have been shown to be capable of producing antimicrobial peptides upon exposure to different bacteria. As a result, antimicrobial peptides can be considered as novel agents for the treatment of infectious diseases. The purpose of this review was to investigate the targets and mechanisms of antimicrobial peptides secreted by MSCs. Biotechnology; Microbiology; Molecular biology; Proteins, Infectious disease; Mesenchymal stem cells; Antimicrobial peptides; Bacteria
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2019.e02652