Assessing Smoking Status and Risk of SARS-CoV-2 Infection: A Machine Learning Approach among Veterans

The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans' Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28...

Full description

Saved in:
Bibliographic Details
Published in:Healthcare (Basel) 2022-07, Vol.10 (7), p.1244
Main Authors: Nono Djotsa, Alice B S, Helmer, Drew A, Park, Catherine, Lynch, Kristine E, Sharafkhaneh, Amir, Naik, Aanand D, Razjouyan, Javad, Amos, Christopher I
Format: Article
Language:English
Subjects:
Age
Body mass index
Cancer
Coronaviruses
COVID-19
Datasets
Diabetes
Feature selection
Hispanic Americans
Hypertension
Infections
Machine learning
Pandemics
Pre-existing conditions
R&D
Research & development
Respiratory diseases
SARS Coronavirus 2
Severe acute respiratory syndrome coronavirus 2
smoking
Variables
veteran
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans' Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28/2021 were classified as: Never Smokers (NS), Former Smokers (FS), and Current Smokers (CS). We report the adjusted odds ratios (aOR) for potential confounders obtained from a cascade machine learning algorithm. We found a 19.6% positivity rate among 1,176,306 veterans tested for SARS-CoV-2 infection. The positivity proportion among NS (22.0%) was higher compared with FS (19.2%) and CS (11.5%). The adjusted odds of testing positive for CS (aOR:0.51; 95%CI: 0.50, 0.52) and FS (aOR:0.89; 95%CI:0.88, 0.90) were significantly lower compared with NS. Four pre-existing conditions, including dementia, lower respiratory infections, pneumonia, and septic shock, were associated with a higher risk of testing positive, whereas the use of the decongestant drug phenylephrine or having a history of cancer were associated with a lower risk. CS and FS compared with NS had lower risks of testing positive for SARS-CoV-2. These findings highlight our evolving understanding of the role of smoking status on the risk of SARS-CoV-2 infection.
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare10071244