Effects of intraoperative different fluid therapy protocols on postoperative renal functions

• Published in: BMC anesthesiology 2024-08, Vol.24 (1), p.299-6, Article 299
• Main Authors: Dumanlı Özcan, Ayça Tuba, Taş, Nisan, Ersoy, Umut Cahit, Yamen, Kevser, Yılmaz, Yusuf, Özcan, Erdal, Ceylan, Cengiz, Güleç, Handan
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal surgery; Adolescent; Adult; Aged; Bleeding; Blood Loss, Surgical; Care and treatment; Case-Control Studies; Clinical trials; Creatinine; Crystalloid Solutions - administration & dosage; Endothelium; Female; Fluid Therapy - methods; Hemodynamics; Humans; Intraoperative Care - methods; KDIGO criteria; Kidney - physiology; Kidney diseases; Male; Medical research; Medicine, Experimental; Middle Aged; Pancreatic surgery; Patients; Prospective Studies; Remifentanil; Renal function; Statistical analysis; Surgery; Targeted fluid therapy; Young Adult
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-024-02679-3

Planning intraoperative fluid therapy in patients undergoing major abdominal surgery is important. It was aimed to define the difference between fluid therapy protocols for renal function, bleeding and postoperative service follow-ups. This is an observational case-controlled prospective study. Sixty patients aged 18-65 years who had undergone pancreatic surgery between December 2023- February 2023 were included in the study. Liberal (Group 1; n = 30) and targeted fluid therapies (Group 2; n = 30) were administered to the patients. Liberal fluid therapy was planned with 8-10 ml/kg/h crystalloid infusion. The targeted fluid therapy (TFT) group (Group 2; n = 30) began with a 2 ml/kg/h crystalloid infusion at the baseline. Additional fluid boluses were given in 250 ml of colloid infused over 10 min if PVI was > 13% for at least five minutes. The patients were staged using the KDIGO (Kidney Disease: Improving Global Outcomes) criteria. The amount of bleeding during surgery was recorded for both groups. No significant difference was observed in postoperative renal function. A significant difference was observed in the amount of intraoperative bleeding. The amount of bleeding was greater in patients managed with liberal fluid therapy. No significant difference was observed between the groups in the oral intake (hour), drain withdrawal (hour) mobilization (hour) and discharge (day) times and there isn't any statistically significant differance between groups in cost effectivity (p>0.05). Kidney function was preserved during individualized targeted fluid therapy using non-invasive haemodynamic monitoring parameters.