Association between MUC1 rs4072037 polymorphism and Helicobacter pylori in patients with gastric cancer

The gene encodes glycoproteins attached to cell membrane that play a protective role in gastric cancer and protect epithelial surfaces against external factors such as . infection can induce a cascade of innate and acquired immune responses in gastric mucosa. Relationship between rs4072037G>A pol...

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Bibliographic Details
Published in:Caspian journal of internal medicine 2024, Vol.15 (1), p.132-140
Main Authors: Shekarriz, Ramin, Jabbari, Hadi, Alikhani, Reza, Alizadeh-Navaei, Reza, Hashemi-Soteh, Mohammad Bagher
Format: Article
Language:English
Subjects:
a polymorphism
gastric cancer
genotype
h. pylori
muc1 5640g
pcr-rflp
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Summary:The gene encodes glycoproteins attached to cell membrane that play a protective role in gastric cancer and protect epithelial surfaces against external factors such as . infection can induce a cascade of innate and acquired immune responses in gastric mucosa. Relationship between rs4072037G>A polymorphism of gene and increased susceptibility to infection aimed to investigate in patients with gastric cancer in Mazandaran, northern Iran. A case-control study was conducted on 99 patients with gastric cancer ( positive and negative) and 98 controls ( positive and negative) without gastric cancer (confirmed by pathological biopsy samples obtained during endoscopy). infection was diagnosed by histological examination using Giemsa staining. Genomic DNA extracted from peripheral blood was analyzed by PCR-RFLP technique. Analysis of all genetic models showed no significant relationship between rs4072037G>A polymorphism and risk of gastric cancer (GC). The relationship between infection and rs4072037G>A polymorphism showed an increased susceptibility to gastric cancer in both positive and negative groups (including case and control groups). The genetic model of GA/GG and - positive versus GA/GG and -negative showed a significantly increased susceptibility to gastric cancer (OR=0.251, CI: 0.128-0.493, P=0.000). These findings indicate that rs4072037G>A polymorphism may interact with infection to increase the risk of GC.
ISSN:2008-6164
2008-6172
DOI:10.22088/cjim.15.1.15