Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia

Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. While searching for an anti-FDP reagent, we found that green tea extract (GTE) and fractions rich in flavonol glycosides (FLGs) and crude tea polysaccharides (CTPs) had p...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2232-2232, Article 2232
Main Authors: Kim, Juewon, Choi, Hyunjung, Choi, Dong-Hwa, Park, Kyuhee, Kim, Hyung-June, Park, Miyoung
Format: Article
Language:English
Subjects:
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Air pollution
Cilia
Combined treatment
Dust
Epithelial cells
Flavonols
Functional foods & nutraceuticals
Gene expression
Glycosides
Green tea
Humanities and Social Sciences
Inflammation
multidisciplinary
Outdoor air quality
Oxidative stress
Polysaccharides
Respiratory tract
Saccharides
Science
Science (multidisciplinary)
Tea
Toxins
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Summary:Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. While searching for an anti-FDP reagent, we found that green tea extract (GTE) and fractions rich in flavonol glycosides (FLGs) and crude tea polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line. The GTE, FLGs, and CTPs significantly increased viability and lowered oxidative stress levels in FDP-treated cells. Combined treatment with GTE, FLGs, and CTPs also exerted synergistic protective effects on cells and attenuated FDP-induced elevations in inflammatory gene expression. Moreover, the green tea components increased the proportion of ciliated cells and upregulated ciliogenesis in the airway in FDP-stimulated BEAS-2B cells. Our findings provide insights into how natural phytochemicals protect the airway and suggest that green tea could be used to reduce FDP-induced airway damage as an ingredient in pharmaceutical, nutraceutical, and also cosmeceutical products.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81989-9