The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender

To study the diabetes related CVD risk between men and women of different ages. Hazards ratios (HRs) (95%CI) for acute CHD and ischaemic stroke events were estimated based on data of Finnish and Swedish cohorts of 5111 women and 4167 men. 182 (3.6%) women and 348 (8.4%) men had CHD and 129 (2.5%) wo...

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Published in:Cardiovascular diabetology 2009-03, Vol.8 (1), p.17-17
Main Authors: Hyvärinen, Marjukka, Tuomilehto, Jaakko, Laatikainen, Tiina, Söderberg, Stefan, Eliasson, Mats, Nilsson, Peter, Qiao, Qing
Format: Article
Language:English
Subjects:
Adult
Aged
Annan klinisk medicin
Clinical Medicine
Cohort Studies
Coronary Disease - epidemiology
Coronary Disease - etiology
Diabetes Complications - epidemiology
Diabetes Complications - etiology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Klinisk medicin
Male
Medical and Health Sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Middle Aged
Original Investigation
Other Clinical Medicine
Risk Factors
Sex Characteristics
Stroke - epidemiology
Stroke - etiology
Sweden - epidemiology
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Summary:To study the diabetes related CVD risk between men and women of different ages. Hazards ratios (HRs) (95%CI) for acute CHD and ischaemic stroke events were estimated based on data of Finnish and Swedish cohorts of 5111 women and 4167 men. 182 (3.6%) women and 348 (8.4%) men had CHD and 129 (2.5%) women and 137 (3.3%) men ischaemic stroke events. The multivariate adjusted HRs for acute CHD at age groups of 40-49, 50-59 and 60-69 years were 1.00 (1.94), 1.78 (4.23), 3.75 (8.40) in women (men) without diabetes and 4.35 (5.40), 5.49 (9.54) and 8.84 (13.76) in women (men) with diabetes. The corresponding HRs for ischaemic stroke were 1.00 (1.26), 2.48 (2.83) and 5.17 (5.11) in women (men) without diabetes and 4.14 (4.91), 3.32 (6.75) and 13.91 (18.06) in women (men) with diabetes, respectively. CHD risk was higher in men than in women but difference reduced in diabetic population. Diabetes, however, increased stroke risk more in men than in women.
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-8-17