Roles of Splicing Factors in Hormone-Related Cancer Progression

Splicing of mRNA precursor (pre-mRNA) is a mechanism to generate multiple mRNA isoforms from a single pre-mRNA, and it plays an essential role in a variety of biological phenomena and diseases such as cancers. Previous studies have demonstrated that cancer-specific splicing events are involved in va...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-02, Vol.21 (5), p.1551
Main Authors: Takeiwa, Toshihiko, Mitobe, Yuichi, Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Inoue, Satoshi
Format: Article
Language:English
Subjects:
breast cancer
dbhs family proteins
hnrnps
prostate cancer
Review
sr proteins
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Summary:Splicing of mRNA precursor (pre-mRNA) is a mechanism to generate multiple mRNA isoforms from a single pre-mRNA, and it plays an essential role in a variety of biological phenomena and diseases such as cancers. Previous studies have demonstrated that cancer-specific splicing events are involved in various aspects of cancers such as proliferation, migration and response to hormones, suggesting that splicing-targeting therapy can be promising as a new strategy for cancer treatment. In this review, we focus on the splicing regulation by RNA-binding proteins including Drosophila behavior/human splicing (DBHS) family proteins, serine/arginine-rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) in hormone-related cancers, such as breast and prostate cancers.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms21051551