Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development

Co-crystal innovation is an opportunity in drug development for both scientists and industry. In line with the “green pharmacy” concept for obtaining safer methods and advanced pharmaceutical products, co-crystallization is one of the most promising approaches to find novel patent drugs, including n...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-07, Vol.26 (14), p.4185
Main Authors: Nugrahani, Ilma, Parwati, Rismaya Desti
Format: Article
Language:English
Subjects:
Acids
Analgesics
Anti-inflammatory agents
Bioavailability
challenges
co-crystal
Cocrystallization
Crystallization
Crystals
Drug development
Fourier transforms
Hydrogen bonds
Inflammation
Mechanical properties
Methods
Microenvironments
multicompoent
Nonsteroidal anti-inflammatory drugs
NSAID
Pain
Permeability
progress
Review
Salt
salt co-crystal
Solvents
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Summary:Co-crystal innovation is an opportunity in drug development for both scientists and industry. In line with the “green pharmacy” concept for obtaining safer methods and advanced pharmaceutical products, co-crystallization is one of the most promising approaches to find novel patent drugs, including non-steroidal anti-inflammatory drugs (NSAID). This kind of multi-component system improves previously poor physicochemical and mechanical properties through non-covalent interactions. Practically, there are many challenges to find commercially viable co-crystal drugs. The difficulty in selecting co-formers becomes the primary problem, followed by unexpected results, such as decreased solubility and dissolution, spring and parachute effect, microenvironment pH effects, changes in instability, and polymorphisms, which can occur during the co-crystal development. However, over time, NSAID co-crystals have been continuously updated regarding co-formers selection and methods development.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26144185