Recent insights on nanomedicine for augmented infection control

Antimicrobial agents have been widely investigated for protecting against microbial infections in modern health. Drug-related limitations, poor bioavailability, toxicity to mammalian cells, and frequent bacteria drug resistance are major challenges faced when exploited in nanomedicine forms. Specifi...

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Bibliographic Details
Published in:International journal of nanomedicine 2019-04, Vol.14, p.2301-2325
Main Authors: Singh, Sima, Hussain, Afzal, Shakeel, Faiyaz, Ahsan, Mohamed Jawed, Alshehri, Sultan, Webster, Thomas J, Lal, Uma Ranjan
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacology
Antimicrobial agents
Bacteria
Biosafety
Cells (Biology)
Drug Carriers - chemistry
Drug Delivery
Drug Delivery Systems
Drug resistance
Health aspects
Humans
Infection Control
Medical research
Metals (Materials)
Microbial drug resistance
Nanomedicine - methods
Nanomedicines
Nanostructures - chemistry
Nanostructures - ultrastructure
Oxides
Pathogenic microorganisms
Polymer industry
Polymers
Retirement benefits
Review
Setting (Literature)
Toxicity
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Summary:Antimicrobial agents have been widely investigated for protecting against microbial infections in modern health. Drug-related limitations, poor bioavailability, toxicity to mammalian cells, and frequent bacteria drug resistance are major challenges faced when exploited in nanomedicine forms. Specific attention has been paid to control nanomaterial-based infection against numerous challenging pathogens in addition to improved drug delivery, targeting, and pharmacokinetic (PK) profiles, and thus, efficient antimicrobials have been fabricated using diverse components (metals, metal oxides, synthetic and semisynthetic polymers, natural or biodegradable polymers, etc). The present review covers several nanocarriers delivered through various routes of administration, highlighting major findings to control microbial infection as compared to using the free drug. Results over the past decade support the consistent development of various nanomedicines capable of improving biological significance and therapeutic benefits against an array of microbial strains. Depending on the intended application of nanomedicine, infection control will be challenged by various factors such as weighing the risk-benefits in healthcare settings, nanomaterial-induced (eco)toxicological hazards, frequent development of antibiotic resistance, scarcity of in vivo toxicity data, and a poor understanding of microbial interactions with nanomedicine at the molecular level. This review summarizes well-established informative data for nanomaterials used for infection control and safety concerns of nanomedicines to healthcare sectors followed by the significance of a unique "safe-by-design" approach.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S170280