The Utility of Novel Kidney Injury Biomarkers in Early Detection of CSA-AKI

Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common complications of cardiac surgery procedures. In this study, the authors attempt to provide new data regarding the application of novel kidney injury biomarkers in the early diagnostics of CSA-AKI. 128 adult patients u...

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Published in:International journal of molecular sciences 2022-12, Vol.23 (24), p.15864
Main Authors: Udzik, Jakub, Waszczyk, Aleksandra, Wojciechowska-Koszko, Iwona, Kwiatkowski, Paweł, Roszkowska, Paulina, Rogulska, Karolina, Safranow, Krzysztof, Biskupski, Andrzej, Kwiatkowski, Sebastian, Kwiatkowska, Ewa
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Acute-Phase Proteins
Adult
Biomarkers
cardiac surgery
Cardiac Surgical Procedures - adverse effects
cardiopulmonary by-pass
Coronary vessels
Creatinine
CSA-AKI
Cytokines
Heart
Heart surgery
Humans
Interleukin 8
Ischemia
Kidney
kidney injury biomarkers
Kidneys
Lipocalin-2
Lipocalins
Mortality
Patients
Plasma
Predictive Value of Tests
Proto-Oncogene Proteins
Regression analysis
Risk analysis
Risk factors
Surgery
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Urine
Weaning
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Summary:Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common complications of cardiac surgery procedures. In this study, the authors attempt to provide new data regarding the application of novel kidney injury biomarkers in the early diagnostics of CSA-AKI. 128 adult patients undergoing elective cardiac surgery procedures with the use of cardiopulmonary by-pass (CPB) were enrolled in this study. Novel kidney injury biomarkers were marked in the plasma and urine 6 h after weaning from the CPB. A significant difference in the postoperative biomarkers' concentration between the AKI and no-AKI group was found, regarding plasma IL-8, plasma TNF-α and urine NGAL, normalized for creatinine excretion (NGAL/Cr). These were also independent predictors of CSA-AKI. An independent risk factor for CSA-AKI proved to be preoperative CKD. Plasma IL-8 and TNF-α, as well as urine NGAL/Cr, are independent early indicators of CSA-AKI and pose a promising alternative for creatinine measurements. The cut-off points for these biomarkers proposed in this investigation should be confronted with more data and revised to achieve a suitable diagnostic value.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232415864