Effect of Prunus cerasus (Sour Cherry) on Nephrolithiasis in Children: The First Noninferiority Two-Arm Randomized Clinical Trial

 The present study evaluated the effect of Prunus cerasus (sour cherry) on children with nephrolithiasis.  We conducted a randomized noninferiority controlled trial to evaluate the therapeutic efficacy of P. cerasus among children with nephrolithiasis. Subjects in the intervention group received 1.2...

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Bibliographic Details
Published in:Urology research and practice 2024-03, Vol.50 (2), p.134-138
Main Authors: Ghane-Sharbaf, Fatemeh, Reza-Jafar, Zahra, Bakhtiari, Elham, Saadat, Sara
Format: Article
Language:English
Subjects:
Clinical Trial
Pediatric Urology
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Summary: The present study evaluated the effect of Prunus cerasus (sour cherry) on children with nephrolithiasis.  We conducted a randomized noninferiority controlled trial to evaluate the therapeutic efficacy of P. cerasus among children with nephrolithiasis. Subjects in the intervention group received 1.25 mL/kg of cherry concentrate once daily for 2 months, while the control group received 1 mL/kg Polycitra-K, which consists of 220 g citrate potassium and 68 g citric acid in 1000 mL sterile water. The major outcome was sonographically determined number and sizes of kidney stones, which were assessed before and after the trial.  Sixty-eight children completed the study. At trial onset, both groups were similar in baseline characteristics (P >.05). In within-group analysis, the number of stones significantly decreased in both groups (P
ISSN:2980-1478
2980-1478
DOI:10.5152/tud.2024.23206