Electrocatalytic Study of Paracetamol at a Single-Walled Carbon Nanotube/Nickel Nanocomposite Modified Glassy Carbon Electrode

A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltamme...

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Bibliographic Details
Published in:Advances in materials science and engineering 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Mohd Zawawi, Ruzniza, Zainal, Zulkarnain, Tan, Wee-Tee, Ngai , Koh Sing, Juan, Joon Ching
Format: Article
Language:English
Subjects:
Analgesics
Attachment
Calibration
Carbon
Electrodes
Electrolytes
Glassy carbon
Morphology
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Nanotechnology
Nanotubes
Nickel
Pharmaceutical industry
Potassium
Single wall carbon nanotubes
Studies
Voltammetry
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Summary:A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltammetry study on the effect of paracetamol concentration, scan rate, pH, and temperature at a SWCNT/Ni-modified electrode in the determination of paracetamol. The characterization of the SWCNT/Ni/GCE was performed by cyclic voltammetry. Variable pressure scanning electron microscopy (VPSEM) and energy dispersive X-ray (EDX) spectrometer were used to examine the surface morphology and elemental profile of the modified electrode, respectively. Cyclic voltammetry showed significant enhancement in peak current for the determination of paracetamol at the SWCNT/Ni-modified electrode. A linear calibration curve was obtained for the paracetamol concentration between 0.05 and 0.50 mM. The SWCNT/Ni/GCE displayed a sensitivity of 64 mA M−1 and a detection limit of 1.17 × 10−7 M in paracetamol detection. The proposed electrode can be applied for the determination of paracetamol in real pharmaceutical samples with satisfactory performance. Results indicate that electrodes modified with SWCNT and nickel nanoparticles exhibit better electrocatalytic activity towards paracetamol.
ISSN:1687-8434
1687-8442
DOI:10.1155/2015/742548