Cutaneous Lesions Presenting as Recurrent Annular Erythema in a Child with Juvenile Myelomonocytic Leukemia, Coeliac Disease, and CALMs: The Myriad Manifestations of RASopathy

In neurofibromatosis type 1 (NF-1), a Ras-pathway mutation disorder both celiac disease and juvenile myelomonocytic leukemia (JMML) have been found in association. A 3-year-old male child presented to us with annular erythema and cafe-au-lait macules (>6 in number). On investigation, he was found...

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Bibliographic Details
Published in:Indian journal of paediatric dermatology 2021-01, Vol.22 (1), p.66-69
Main Authors: Sahoo, Bishnupriya, Ganjoo, Shikhar, Sawhney, Mohinder, Nagger, Seema
Format: Article
Language:English
Subjects:
annular erythema
Children
coeliac disease
Diseases
Erythema
Genetic aspects
juvenile chronic myelomonocytic leukemia
Leukemia
neurofibromatosis
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Summary:In neurofibromatosis type 1 (NF-1), a Ras-pathway mutation disorder both celiac disease and juvenile myelomonocytic leukemia (JMML) have been found in association. A 3-year-old male child presented to us with annular erythema and cafe-au-lait macules (>6 in number). On investigation, he was found to have JMML and celiac disease. A child with early manifestation of NF1 in association with JMML and celiac disease is an even rarer presentation.
ISSN:2319-7250
DOI:10.4103/ijpd.IJPD_79_20