Exploring the late maturation of an intrinsic episodic memory network: A resting-state fMRI study

Previous research suggests that episodic memory relies on functional neural networks,which are present even in the absence of an explicit task. The regions that integrate.these networks and the developmental changes in intrinsic functional connectivity.remain elusive. In the present study, we outlin...

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Bibliographic Details
Published in:Developmental cognitive neuroscience 2024-12, Vol.70, p.101453, Article 101453
Main Authors: Andrade, Miguel Ângelo, Raposo, Ana, Andrade, Alexandre
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adult
Brain - physiology
Brain Mapping - methods
Episodic memory network
Female
Humans
Intrinsic cognitive networks
Late maturation
Magnetic Resonance Imaging - methods
Male
Memory development
Memory, Episodic
Nerve Net - diagnostic imaging
Nerve Net - physiology
Original Research
Rest - physiology
Resting-state fMRI
Young Adult
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Summary:Previous research suggests that episodic memory relies on functional neural networks,which are present even in the absence of an explicit task. The regions that integrate.these networks and the developmental changes in intrinsic functional connectivity.remain elusive. In the present study, we outlined an intrinsic episodic memory network.(iEMN) based on a systematic selection of functional connectivity studies, and.inspected network differences in resting-state fMRI between adolescents (13–17 years.old) and adults (23–27 years old) from the publicly available NKI-Rockland Sample.Through a review of brain regions commonly associated with episodic memory.networks, we identified a potential iEMN composed by 14 bilateral ROIs, distributed.across temporal, frontal and parietal lobes. Within this network, we found an increase.in resting-state connectivity from adolescents to adults between the right temporal pole.and two regions in the right lateral prefrontal cortex. We argue that the coordination of.these brain regions, connecting areas of semantic processing and areas of controlled.retrieval, arises as an important feature towards the full maturation of the episodic.memory system. The findings add to evidence suggesting that adolescence is a key.period in memory development and highlights the role of intrinsic functional.connectivity in such development. •Resting-state fMRI study on late maturation of an intrinsic episodic memory network•Identification of 14 ROIs forming a potential intrinsic episodic memory network•Protracted maturation of this resting-state network during adolescence•Age-related connectivity increases between temporal pole and prefrontal cortex•Semantic and controlled processing key in maturation of episodic memory
ISSN:1878-9293
1878-9307
1878-9307
DOI:10.1016/j.dcn.2024.101453