Step-by-Step Design of New Theranostic Nanoformulations: Multifunctional Nanovectors for Radio-Chemo-Hyperthermic Therapy under Physical Targeting

While investigating the possible synergistic effect of the conventional anticancer therapies, which, taken individually, are often ineffective against critical tumors, such as central nervous system (CNS) ones, the design of a theranostic nanovector able to carry and deliver chemotherapy drugs and m...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-07, Vol.26 (15), p.4591
Main Authors: Ansari, Shoeb Anwar, Ficiarà, Eleonora, D’Agata, Federico, Cavalli, Roberta, Nasi, Lucia, Casoli, Francesca, Albertini, Franca, Guiot, Caterina
Format: Article
Language:English
Subjects:
Biodegradability
Biodegradation
Body temperature
Cancer therapies
Central nervous system
Chemotherapy
Curcumin
Doxorubicin
Drug development
Drugs
Fever
Hemoglobin
Hyperthermia
Hypoxia
Iron oxides
magnetic driving
Magnetic fields
Magnetic resonance imaging
Microscopy
Nanoparticles
nanostructure
oxygen
Perfluorocarbons
Radiation therapy
Radiosensitizers
Respiratory distress syndrome
SPIONs
Synergistic effect
theranostic
Transplants & implants
Tumors
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Summary:While investigating the possible synergistic effect of the conventional anticancer therapies, which, taken individually, are often ineffective against critical tumors, such as central nervous system (CNS) ones, the design of a theranostic nanovector able to carry and deliver chemotherapy drugs and magnetic hyperthermic agents to the target radiosensitizers (oxygen) was pursued. Alongside the original formulation of polymeric biodegradable oxygen-loaded nanostructures, their properties were fine-tuned to optimize their ability to conjugate therapeutic doses of drugs (doxorubicin) or antitumoral natural substances (curcumin). Oxygen-loaded nanostructures (diameter = 251 ± 13 nm, ζ potential = −29 ± 5 mV) were finally decorated with superparamagnetic iron oxide nanoparticles (SPIONs, diameter = 18 ± 3 nm, ζ potential = 14 ± 4 mV), producing stable, effective and non-agglomerating magnetic nanovectors (diameter = 279 ± 17 nm, ζ potential = −18 ± 7 mV), which could potentially target the tumoral tissues under magnetic driving and are monitorable either by US or MRI imaging.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26154591