Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

•Constipation occurs in approximately > 60 % of IRBD patients.•CAS-J can be used to assess bowel movement frequency and difficult defecation.•CAS-J score was higher for women than for men in IRBD.•CAS-J scores predict phenoconversion to PD or DLB.•Treatments that relieve constipation should be co...

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Bibliographic Details
Published in:Clinical parkinsonism & related disorders 2024-01, Vol.11, p.100269, Article 100269
Main Authors: Miyamoto, Tomoyuki, Nakajima, Itsuo, Arikawa, Takuo, Miyamoto, Masayuki
Format: Article
Language:English
Subjects:
Bowel habits
Bowel movement frequency
Constipation assessment scale
Dementia with Lewy bodies
Isolated REM sleep behavior disorder
Original
Parkinson’s disease
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Summary:•Constipation occurs in approximately > 60 % of IRBD patients.•CAS-J can be used to assess bowel movement frequency and difficult defecation.•CAS-J score was higher for women than for men in IRBD.•CAS-J scores predict phenoconversion to PD or DLB.•Treatments that relieve constipation should be considered in IRBD. This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia with Lewy bodies (DLB) in middle-aged and older adults. We used a validated Japanese version of the Constipation Assessment Scale (CAS-J) to evaluate bowel habits over 1 month in 117 men aged 50–86 years and 34 women aged 56–86 years with video-polysomnography-confirmed IRBD and 22 controls. Furthermore, we performed a longitudinal assessment of outcomes at follow-up visits. The CAS-J score was higher in the 22 IRBD patients than in 22 age- and gender-matched paired controls. In 151 IRBD patients, the CAS-J score was higher for women than for men. At baseline, the CAS-J score was similar between patients who developed PD and DLB, but the three IRBD patients who developed multiple system atrophy had a low CAS-J score. Those with constipation (CAS-J score ≥ 2) converted to PD or DLB in a significantly shorter time duration (i.e., time frame for phenoconversion) than those with CAS-J score 
ISSN:2590-1125
2590-1125
DOI:10.1016/j.prdoa.2024.100269