Generation of induced pluripotent stem cell line-NTUHi001-A from a premature ovarian failure patient with Turner's syndrome mosaicism

Turner's syndrome (TS) is one of the main causes of premature ovarian failure (POF). However, the mechanisms underlying POF are difficult to study due to the lack of suitable disease models. Herein, we have generated a human induced pluripotent stem cell (hiPSC) line derived from the peripheral...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research 2019-05, Vol.37, p.101422-101422, Article 101422
Main Authors: Lu, Chen-Yu, Chen, Yu-An, Syu, Shih-Han, Lu, Huai-En, Ho, Hong-Nerng, Chen, Hsin-Fu
Format: Article
Language:English
Subjects:
Adult
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Female
Humans
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - pathology
Mosaicism
Phenotype
Primary Ovarian Insufficiency - complications
Primary Ovarian Insufficiency - genetics
Primary Ovarian Insufficiency - pathology
Turner Syndrome - complications
Turner Syndrome - genetics
Turner Syndrome - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Turner's syndrome (TS) is one of the main causes of premature ovarian failure (POF). However, the mechanisms underlying POF are difficult to study due to the lack of suitable disease models. Herein, we have generated a human induced pluripotent stem cell (hiPSC) line derived from the peripheral blood mononuclear cells of a female patient with Turner's syndrome mosaicism via integration-free Sendai-virus system. The hiPSCs were confirmed with a 45, X karyotype and the acquisition of pluripotency. It's likely that hiPSCs can serve as a feasible cellular model for further pathophysiological studies of POF cases, especially for those originating in TS.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2019.101422