Enhancement of Bone-Forming Ability on Beta-Tricalcium Phosphate by Modulating Cellular Senescence Mechanisms Using Senolytics

Various stresses latently induce cellular senescence that occasionally deteriorates the functioning of surrounding tissues. Nevertheless, little is known about the appearance and function of senescent cells, caused by the implantation of beta-tricalcium phosphate (β-TCP)-used widely in dentistry and...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12415
Main Authors: Wang, Xinchen, Honda, Yoshitomo, Zhao, Jianxin, Morikuni, Hidetoshi, Nishiura, Aki, Hashimoto, Yoshiya, Matsumoto, Naoyuki
Format: Article
Language:English
Subjects:
Absorbable Implants
Acid phosphatase
Acid phosphatase (tartrate-resistant)
Acid resistance
Administration, Oral
Animals
beta-tricalcium phosphate
Biomarkers
Bone diseases
Bone Diseases - drug therapy
bone formation
Bone growth
Bone Regeneration - drug effects
Bone Substitutes - chemistry
Bone Substitutes - therapeutic use
Calcium phosphates
Calcium Phosphates - chemistry
Calcium Phosphates - therapeutic use
Calvaria
Cell cycle
cellular senescence
Cellular Senescence - drug effects
Computed tomography
Dasatinib - administration & dosage
Dentistry
DNA damage
Fourier transforms
Galactosidase
Granular materials
Granule cells
Implantation
Leukemia
Male
Oral administration
Orthopedics
Osteoblasts - drug effects
Osteoblasts - metabolism
Osteogenesis
Osteogenesis - drug effects
Oxidative stress
Oxidative Stress - drug effects
Quercetin
Quercetin - administration & dosage
Rats
Rats, Sprague-Dawley
Reactive oxygen species
Reactive Oxygen Species - metabolism
Senescence
senolytics
Senotherapeutics - administration & dosage
Skin & tissue grafts
Skull - diagnostic imaging
Skull - metabolism
Skull - pathology
Spectrum analysis
Staining
Treatment Outcome
Tricalcium phosphate
X-Ray Microtomography - methods
β-Galactosidase
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Summary:Various stresses latently induce cellular senescence that occasionally deteriorates the functioning of surrounding tissues. Nevertheless, little is known about the appearance and function of senescent cells, caused by the implantation of beta-tricalcium phosphate (β-TCP)-used widely in dentistry and orthopedics for treating bone diseases. In this study, two varying sizes of β-TCP granules (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222212415