Re-irradiation of recurrent vertebral metastasis after two previous spinal cord irradiation: A case report

Management of a recurrent vertebral metastasis in a situation of previously irradiated spinal cord is a challenging clinical dilemma. We report a first case of second retreatment of a spinal metastasis initially irradiated with standard radiotherapy and stereotactic body radiation therapy (SBRT), wh...

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Bibliographic Details
Published in:Frontiers in oncology 2023-01, Vol.12, p.995376
Main Authors: Bentahila, Rita, Kinj, Rémy, Huck, Constance, El Houat, Yasmine, Mampuya, Ange, Tuleasca, Constantin, Ozsahin, Mahmut, Bourhis, Jean, Schiappacasse, Luis
Format: Article
Language:English
Subjects:
Oncology
radiosurgery
retreatment
spine
stereotactic radiation
vertebral metastases
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Summary:Management of a recurrent vertebral metastasis in a situation of previously irradiated spinal cord is a challenging clinical dilemma. We report a first case of second retreatment of a spinal metastasis initially irradiated with standard radiotherapy and stereotactic body radiation therapy (SBRT), who subsequently progressed with imaging-confirmed local tumor progression at the same level. After a third course of irradiation with SBRT, a complete response was achieved. After 8 months of follow-up, the patients remain free of local recurrence. A third course of vertebral irradiation for a recurrent vertebral metastasis failing to two previous irradiations, in this particular case, have shown the feasibility and efficacy of the technique as a salvage treatment option. This approach could be used in a selected group of patient if an adequate dose is delivered to the target while observing critical tissue tolerance limits.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.995376