COVID-19: Pain Management in Patients with SARS-CoV-2 Infection-Molecular Mechanisms, Challenges, and Perspectives

Since the end of 2019, the whole world has been struggling with the pandemic of the new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Available evidence suggests that pain is a common symptom during Coronavirus Disease 2019 (COVID-19). According to the World Health Organization, many p...

Full description

Saved in:
Bibliographic Details
Published in:Brain sciences 2020-07, Vol.10 (7), p.465
Main Authors: Drożdżal, Sylwester, Rosik, Jakub, Lechowicz, Kacper, Machaj, Filip, Szostak, Bartosz, Majewski, Paweł, Rotter, Iwona, Kotfis, Katarzyna
Format: Article
Language:English
Subjects:
Arthralgia
Chronic pain
coronavirus
Coronaviruses
COVID-19
Cytokines
Disease transmission
Epidemics
Headache
Headaches
Infections
Mechanical ventilation
Middle East respiratory syndrome
Molecular modelling
Muscle pain
Myalgia
Narcotics
Nervous system
neuropathy
Opinion
opioids
Oxygenation
Pain management
Pandemics
Pathogenesis
Patients
Peripheral neuropathy
Pharyngitis
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viral infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since the end of 2019, the whole world has been struggling with the pandemic of the new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Available evidence suggests that pain is a common symptom during Coronavirus Disease 2019 (COVID-19). According to the World Health Organization, many patients suffer from muscle pain (myalgia) and/or joint pain (arthralgia), sore throat and headache. The exact mechanisms of headache and myalgia during viral infection are still unknown. Moreover, many patients with respiratory failure get admitted to the intensive care unit (ICU) for ventilatory support. Pain in ICU patients can be associated with viral disease itself (myalgia, arthralgia, peripheral neuropathies), may be caused by continuous pain and discomfort associated with ICU treatment, intermittent procedural pain and chronic pain present before admission to the ICU. Undertreatment of pain, especially when sedation and neuromuscular blocking agents are used, prone positioning during mechanical ventilation or extracorporeal membrane oxygenation (ECMO) may trigger delirium and cause peripheral neuropathies. This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. A structured prospective evaluation should be undertaken to analyze the probability, severity, sources and adequate treatment of pain in patients with COVID-19 infection.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci10070465