Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the struct...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-10, Vol.15 (10), p.1250
Main Authors: Rajendran, Gayathri, Bhanu, Deepu, Aruchamy, Baladhandapani, Ramani, Prasanna, Pandurangan, Nanjan, Bobba, Kondapa Naidu, Oh, Eun Jung, Chung, Ho Yun, Gangadaran, Prakash, Ahn, Byeong-Cheol
Format: Article
Language:English
Subjects:
Acids
Analysis
Bioflavonoids
chalcones
Chemistry
Claisen–Schmidt condensation
Communicable diseases
Drug discovery
Drug therapy
Flavones
Flavonoids
Health aspects
infectious diseases
Methods
Molecular dynamics
Nanoparticles
Natural products
natural sources
non-infectious diseases
Palladium
Patient outcomes
Pharmaceutical sciences
R&D
Research & development
Review
Solvents
structure–activity relationship
Ultrasonic imaging
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Summary:Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15101250