rs3753394 Complement Factor H (CFH) Gene Polymorphism in Patients with Age-Related Macular Degeneration (AMD) in Indonesian Population

Neovascular Age-related Macular Degeneration (nAMD) is one of the major factors for blindness and impaired visual acuity in elderly people. The aim of this study was CFH gene screening in Age-Related Macular Degeneration patients in Indonesia. This study was performed in 106 AMD patients and 104 con...

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Bibliographic Details
Published in:BIO Web of Conferences 2021, Vol.41, p.6001
Main Authors: Supanji, Supanji, Perdamaian, Ayudha Bahana Ilham, Anindita, Dinda Ajeng, Widayanti, Tri Wahyu, Wardhana, Firman Setya, Sasongko, Muhammad Bayu, Prayogo, Mohammad Eko, Agni, Angela Nurini, Oka, Chio
Format: Article
Language:English
Subjects:
Acuity
Age
Age related diseases
Blindness
Color vision
Complement factor H
Eye diseases
Gene polymorphism
Genetics
Informed consent
Macular degeneration
Photography
Polymerase chain reaction
Polymorphism
Restriction fragment length polymorphism
Visual acuity
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Summary:Neovascular Age-related Macular Degeneration (nAMD) is one of the major factors for blindness and impaired visual acuity in elderly people. The aim of this study was CFH gene screening in Age-Related Macular Degeneration patients in Indonesia. This study was performed in 106 AMD patients and 104 controls for genomic markers in the Complement Factor H ( CFH ). The diagnosis of AMD was carried out by retinal specialists based on color fundus photography and optical coherence tomography. Informed consent was given to patients then proceed to blood sampling and recording of body parameters (BMI, smoking, other systemic diseases). CFH polymorphisms were then analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP). There was no association between genetics polymorphism with nAMD. From the research can be inferred that association between genetics polymorphism with nAMD was insignificant.
ISSN:2117-4458
2273-1709
2117-4458
DOI:10.1051/bioconf/20214106001