Altered Cerebral Vasoreactivity on Transcranial Color-Coded Sonography Related to Akinetic-Rigid Phenotype of Parkinson's Disease: Interim Analysis of a Cross-Sectional Study

• Published in: Brain sciences 2023-04, Vol.13 (5), p.709
• Main Authors: Brisson, Rodrigo Tavares, Fernandes, Rita de Cássia Leite, Arruda, Josevânia Fulgêncio de Lima, Rocha, Thiffanny Cristini Cassiano da S M, Santos, Nathália de Góes Duarte, Silva, Liene Duarte, de Lima, Marco Antônio Sales Dantas, de Rosso, Ana Lucia Zuma
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Apnea; Basal ganglia; Brief Report; Carbon dioxide; Central nervous system diseases; cerebral hemodynamics; cerebral vasoreactivity; cerebrovascular disease; Cerebrovascular diseases; Cross-sectional studies; Diabetes; Diagnostic imaging; Flow velocity; Genotype & phenotype; Hemodynamics; Hypertension; Leukoaraiosis; Magnetic resonance imaging; Movement disorders; Neurodegenerative diseases; Neuroimaging; Parkinson's disease; Patients; Phenotypes; Risk factors; Tremor; Tremor (Muscular contraction); Ultrasonic imaging; ultrasound application; Ultrasound imaging
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci13050709

A correlation between worse functional outcomes in Parkinson's disease (PD) patients with cerebrovascular disease (CVD) or the Akinetic-rigid phenotype has been argued in recent studies. We aimed to evaluate the association of cerebral hemodynamics impairments, assessed by Transcranial Color-coded Doppler sonography (TCCS), on PD patients with different phenotypes of the disease and with risk factors for CVD. Idiopathic PD patients (n = 51) were divided into motor subtypes: Akinetic-rigid (AR) (n = 27) and Tremor-dominant (TD) (n = 24) and into two groups regarding vascular risk factors: when ≥2 were present (PDvasc) (n = 18) and