Combined Application of Dexamethasone and Tranexamic Acid to Reduce the Postoperative Inflammatory Response and Improve Functional Outcomes in Total Hip Arthroplasty

Objective To evaluate the efficacy and safety of combined use of tranexamic acid (TXA) and dexamethasone (DEX) for anti‐inflammatory and clinical outcomes after total hip arthroplasty (THA). Methods A total of 100 patients were included in this randomized, controlled study. Patients in the TXA + DEX...

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Bibliographic Details
Published in:Orthopaedic surgery 2020-04, Vol.12 (2), p.582-588
Main Authors: An, Yu‐zhang, Xu, Ming‐deng, An, Yu‐cheng, Liu, Huan, Zheng, Ming, Jiang, Dian‐ming
Format: Article
Language:English
Subjects:
Antifibrinolytic agents
C-reactive protein
Care and treatment
Central nervous system depressants
Clinical
Clinical outcomes
Dexamethasone
Hip joint
Joint replacement surgery
Medical research
Medicine, Experimental
Nausea
Pain
Patient outcomes
Postoperative period
Steroids
Surgical outcomes
Total hip arthroplasty
Tranexamic acid
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Summary:Objective To evaluate the efficacy and safety of combined use of tranexamic acid (TXA) and dexamethasone (DEX) for anti‐inflammatory and clinical outcomes after total hip arthroplasty (THA). Methods A total of 100 patients were included in this randomized, controlled study. Patients in the TXA + DEX group were administered TXA at a dose of 15 mg/kg, which was repeated 3 h after THA, and received 20 mg DEX. In contrast, patients in the TXA group were administered TXA at a dose of 15 mg/kg, which was repeated at 3 h postoperatively. C‐reactive protein (CRP), interleukin‐6 (IL‐6) and pain levels, incidence of postoperative nausea and vomiting (PONV), total blood loss and transfusion rates, postoperative fatigue, range of motion (ROM), length of hospital stay (LOS), analgesic rescue and antiemetic rescue consumption, and complications were compared in both groups. Results The CRP and IL‐6 levels were lower in the TXA + DEX group than in the TXA group (all P 
ISSN:1757-7853
1757-7861
DOI:10.1111/os.12664