The Impact of Ulmus macrocarpa Extracts on a Model of Sarcopenia-Induced C57BL/6 Mice

Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Hance, a traditional herbal remedy, to address muscle loss and...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (11), p.6197
Main Authors: Lee, Chan Ho, Kwon, Yeeun, Park, Sunmin, Kim, TaeHee, Kim, Min Seok, Kim, Eun Ji, Jung, Jae In, Min, Sangil, Park, Kwang-Hyun, Jeong, Jae Hun, Choi, Sun Eun
Format: Article
Language:English
Subjects:
Aging
Animals
anti-inflammatory
antioxidant
Antioxidants
Apoptosis
Biomarkers
Body Weight - drug effects
Cancer
Disease Models, Animal
Exercise
Free radicals
Functional foods & nutraceuticals
Gene Expression Regulation - drug effects
Inflammation
Kinases
Male
Mice
Mice, Inbred C57BL
Molecular weight
muscle apoptosis
muscle atrophy
Muscle Fibers, Skeletal - drug effects
Muscles
Musculoskeletal system
Oxidative stress
Oxymetholone
Physical fitness
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Protein expression
Protein synthesis
Proteins
R&D
Research & development
Sarcopenia
Sarcopenia - drug therapy
Ulmus - chemistry
Ulmus macrocarpa Hance
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Summary:Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Hance, a traditional herbal remedy, to address muscle loss and atrophy. We evaluated the effects of extract on various parameters in a muscle atrophy model, including weight, exercise performance, grip strength, body composition, muscle mass, and fiber characteristics. Additionally, we conducted Western blot and RT-PCR analyses to examine muscle protein regulation, apoptosis factors, inflammation, and antioxidants. In a dexamethasone-induced muscle atrophy model, extract administration promoted genes related to muscle formation while reducing those associated with muscle atrophy. It also mitigated inflammation and boosted muscle antioxidants, indicating a potential improvement in muscle atrophy. These findings highlight the promise of extract for developing pharmaceuticals and supplements to combat muscle loss and atrophy, paving the way for clinical applications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25116197