Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism

The trend of fasting until noon (omission or delayed breakfast) is increasingly prevalent in modern society. This eating pattern triggers discordance between endogenous circadian clock rhythms and the feeding/fasting cycle and is associated with an increased incidence of obesity and T2D. Although th...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7154
Main Authors: Jakubowicz, Daniela, Rosenblum, Rachel Chava, Wainstein, Julio, Twito, Orit
Format: Article
Language:English
Subjects:
Body weight
Body Weight - physiology
circadian clock genes
Circadian Rhythm - genetics
Dextrose
diet induced thermogenesis
Energy Metabolism - genetics
Fasting
fasting until noon
Gene expression
Genes
Glucose
Humans
Insulin
Messenger RNA
Muscles
overall glycemia
Physiological aspects
Protein biosynthesis
Proteins
Review
RNA, Messenger
weight loss
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Summary:The trend of fasting until noon (omission or delayed breakfast) is increasingly prevalent in modern society. This eating pattern triggers discordance between endogenous circadian clock rhythms and the feeding/fasting cycle and is associated with an increased incidence of obesity and T2D. Although the underlying mechanism of this association is not well understood, growing evidence suggests that fasting until noon, also known as an "extended postabsorptive state", has the potential to cause a deleterious effect on clock gene expression and to disrupt regulation of body weight, postprandial and overall glycemia, skeletal muscle protein synthesis, and appetite, and may also lead to lower energy expenditure. This manuscript overviews the clock gene-controlled glucose metabolism during the active and resting phases and the consequences of postponing until noon the transition from postabsorptive to fed state on glucose metabolism, weight control, and energy expenditure. Finally, we will discuss the metabolic advantages of shifting more energy, carbohydrates (CH), and proteins to the early hours of the day.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24087154