Serum C-reactive protein level as a biomarker for differentiation of ischemic from hemorrhagic stroke

Cerebrovascular accidents rank first in the frequency and importance among all neurological disease. Although a number of studies had shown increased level of the high sensitive C-reactive protein (hs-CRP) in patients with ischemic stroke, the association of increased hs-CRP with various type of str...

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Bibliographic Details
Published in:Acta medica Iranica 2011, Vol.49 (3), p.149-152
Main Authors: Roudbary, Seyed Ali, Saadat, Farshid, Forghanparast, Kambiz, Sohrabnejad, Reza
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
Brain Ischemia - blood
Brain Ischemia - complications
Brain Ischemia - diagnosis
C-Reactive Protein - analysis
Cerebrovascuar Accidents
Diagnosis, Differential
Female
Hemorrhagic Stroke
High Sensitive C-reactive Protein (hs-CRP)
Humans
Intracranial Hemorrhages - blood
Intracranial Hemorrhages - complications
Intracranial Hemorrhages - diagnosis
Ischemic Stroke
Male
Middle Aged
Stroke - etiology
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Summary:Cerebrovascular accidents rank first in the frequency and importance among all neurological disease. Although a number of studies had shown increased level of the high sensitive C-reactive protein (hs-CRP) in patients with ischemic stroke, the association of increased hs-CRP with various type of stroke especially the assessment hs-CRP level in ischemic and hemorrhagic stroke have not been investigated. In the present study, we assessed the concentration of hs-CRP in patients with documented ischemic and hemorrhagic stroke in the first 24 hours of the onset of symptoms. Thirty-two patients with Ischemic and hemorrhagic stroke were evaluated at neurology department of Poursina Hospital. The presence of baseline vascular risk factors, including hypertension, diabetes mellitus, hypercholesterolemia, obesity, and smoking, was determined. The blood samples were then collected and routine hematology and biochemistry tests were done. hs-CRP levels were determined using a highly sensitive immunonephelometric method. In this cross sectional study, the age of patient varied from 45-85 years (Mean 70.9 ± 9.4). Serum level of hs-CRP in Ischemic patients were 18.92 ± 11.28 and in hemorrhagic group was 2.65 ± 1.7. This relationship was statistically significant (P
ISSN:0044-6025
1735-9694