The Influence of Tart Cherry ( Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial

Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices...

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Published in:Nutrients 2021-04, Vol.13 (5), p.1417
Main Authors: Kimble, Rachel, Keane, Karen M, Lodge, John K, Howatson, Glyn
Format: Article
Language:English
Subjects:
Adults
Anthocyanins
Anti-inflammatory agents
Antioxidants
Blood pressure
C-reactive protein
cardiovascular disease
Cherries
Clinical trials
Diabetes
Dietary supplements
Disease
Exercise
Fruits
Health risks
Heart beat
Heart rate
Hormone replacement therapy
Hypertension
Inflammation
Insulin
Lipids
metabolic health
Metabolism
Metabolites
Middle age
Mortality
Nitric oxide
Physical fitness
Placebos
Prunus cerasus
Questionnaires
Risk analysis
Risk factors
tart cherry
Type 2 diabetes
vascular function
Wave velocity
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Lodge, John K
Howatson, Glyn
description Tart Montmorency cherries (MC) have been shown to be rich in anthocyanins and other phytochemicals known to have anti-inflammatory properties and influence pathways that might improve cardiometabolic health. However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period. Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m ) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 mL of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A], and flow mediated dilation [FMD]) as well as indices of metabolic health (insulin, glucose, lipid profiles, and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months. No effect of the intervention between the groups was observed for vascular function or metabolic health variables following the intervention ( > 0.05). However, MC concentrate was shown to be safe and well-tolerated and, importantly, did not have any deleterious effects on these outcomes. In conclusion, MC has no influence on cardiometabolic indices in middle-aged adults.
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However, there is limited evidence for the longer-term use of tart cherries on these indices. The aim of the current study was to investigate the influence of MC concentrate on cardiometabolic health indices following a 3-month supplementation period. Fifty middle-aged adults (34 males and 16 females; mean ± SD age: 48 ± 6 years and BMI: 27.6 ± 3.7 kg/m ) completed a randomised, placebo-controlled parallel study in which they either received MC or an isocaloric placebo. Participants drank 30 mL of their allocated treatment twice per day for 3 months. Vascular function (blood pressure [BP], heart rate [HR], pulse wave velocity and analysis [PWV/A], and flow mediated dilation [FMD]) as well as indices of metabolic health (insulin, glucose, lipid profiles, and high sensitivity C reactive protein) were measured following an overnight fast before and after the 3 months. No effect of the intervention between the groups was observed for vascular function or metabolic health variables following the intervention ( &gt; 0.05). However, MC concentrate was shown to be safe and well-tolerated and, importantly, did not have any deleterious effects on these outcomes. In conclusion, MC has no influence on cardiometabolic indices in middle-aged adults.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33922493</pmid><doi>10.3390/nu13051417</doi><orcidid>https://orcid.org/0000-0001-8494-2043</orcidid><orcidid>https://orcid.org/0000-0002-1572-9211</orcidid><oa>free_for_read</oa></addata></record>
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source Publicly Available Content Database; PubMed Central
subjects Adults
Anthocyanins
Anti-inflammatory agents
Antioxidants
Blood pressure
C-reactive protein
cardiovascular disease
Cherries
Clinical trials
Diabetes
Dietary supplements
Disease
Exercise
Fruits
Health risks
Heart beat
Heart rate
Hormone replacement therapy
Hypertension
Inflammation
Insulin
Lipids
metabolic health
Metabolism
Metabolites
Middle age
Mortality
Nitric oxide
Physical fitness
Placebos
Prunus cerasus
Questionnaires
Risk analysis
Risk factors
tart cherry
Type 2 diabetes
vascular function
Wave velocity
title The Influence of Tart Cherry ( Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial
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