Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome

ABSTRACT Objective This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women. Methods This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 ...

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Published in:Endocrinology, diabetes & metabolism diabetes & metabolism, 2024-05, Vol.7 (3), p.e490-n/a
Main Authors: Saei Ghare Naz, Marzieh, Mousavi, Maryam, Firouzi, Faezeh, Momenan, Amir Abbas, Azizi, Fereidoun, Ramezani Tehrani, Fahimeh
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Blood Glucose - metabolism
Blood pressure
Cholesterol
Cholesterol, HDL - blood
Cross-Sectional Studies
Diabetes
Enzymes
Exercise
Fatty Liver - etiology
Fatty Liver - physiopathology
Female
Glucose
Humans
Insulin Resistance
Iran - epidemiology
Lipids
Liver - metabolism
Liver diseases
Liver Function Tests
Metabolic disorders
metabolic syndrome
Ovaries
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - physiopathology
Triglycerides - blood
Womens health
Young Adult
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Summary:ABSTRACT Objective This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women. Methods This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]). Result In the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p 
ISSN:2398-9238
2398-9238
DOI:10.1002/edm2.490