Revolutionizing Immunotherapy: Unveiling New Horizons, Confronting Challenges, and Navigating Therapeutic Frontiers in CAR-T Cell-Based Gene Therapies

The CAR-T cell therapy has marked the dawn of new era in the cancer therapeutics and cell engineering techniques. The review emphasizes on the challenges that obstruct the therapeutic efficiency caused by cell toxicities, immunosuppressive tumor environment, and decreased T cell infiltration. In the...

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Bibliographic Details
Published in:ImmunoTargets and therapy 2024-08, Vol.13, p.413-433
Main Authors: Srivastava, Shivani, Tyagi, Anuradha, Pawar, Vishakha Anand, Khan, Nawaid Hussain, Arora, Kavita, Verma, Chaitenya, Kumar, Vinay
Format: Article
Language:English
Subjects:
B cells
car-t cells
Development and progression
gene editing
gene therapies
Genes
Health aspects
immune checkpoint inhibitors
predictive biomarkers
T cells
Tumors
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Summary:The CAR-T cell therapy has marked the dawn of new era in the cancer therapeutics and cell engineering techniques. The review emphasizes on the challenges that obstruct the therapeutic efficiency caused by cell toxicities, immunosuppressive tumor environment, and decreased T cell infiltration. In the interest of achieving the overall survival (OS) and event-free survival (EFS) of patients, the conceptual background of potential target selection and various CAR-T cell design techniques are described which can minimize the off-target effects, reduce toxicity, and thus increase the resilience of CAR-T cell treatment in the haematological malignancies as well as in solid tumors. Furthermore, it delves into cutting-edge technologies like gene editing and synthetic biology, providing new opportunities to enhance the functionality of CAR-T cells and overcome mechanisms of immune evasion. This review provides a comprehensive understanding of the complex and diverse aspects of CAR-T cell-based gene treatments, including both scientific and clinical aspects. By effectively addressing the obstacles and utilizing the capabilities of cutting-edge technology, CAR-T cell therapy shows potential in fundamentally changing immunotherapy and reshaping the approach to cancer treatment.
ISSN:2253-1556
2253-1556
DOI:10.2147/ITT.S474659