ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine

Nanomedicine results from nanotechnology where molecular scale minute precise nanomotors can be used to treat disease conditions. Many such biological nanomotors are found and operate in living systems which could be used for therapeutic purposes. The question is how to build nanomachines that are c...

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Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Ahmad, Zulfiqar, Cox, James L.
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Adenosine triphosphate
Animals
ATP
ATP Synthetase Complexes - antagonists & inhibitors
ATP Synthetase Complexes - chemistry
ATP Synthetase Complexes - metabolism
Bacteria
Bacterial infections
Catalysis
Deoxyribonucleic acid
DNA
DNA polymerase
Dyneins - metabolism
E coli
Enzymes
Flagella - metabolism
Health aspects
Humans
Kinesin - metabolism
Laboratories
Medical research
Medicine, Experimental
Methods
Myosins - metabolism
Nanomedicine
Nanotechnology
Proteins
Review
RNA polymerase
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description Nanomedicine results from nanotechnology where molecular scale minute precise nanomotors can be used to treat disease conditions. Many such biological nanomotors are found and operate in living systems which could be used for therapeutic purposes. The question is how to build nanomachines that are compatible with living systems and can safely operate inside the body? Here we propose that it is of paramount importance to have a workable base model for the development of nanomotors in nanomedicine usage. The base model must placate not only the basic requirements of size, number, and speed but also must have the provisions of molecular modulations. Universal occurrence and catalytic site molecular modulation capabilities are of vital importance for being a perfect base model. In this review we will provide a detailed discussion on ATP synthase as one of the most suitable base models in the development of nanomotors. We will also describe how the capabilities of molecular modulation can improve catalytic and motor function of the enzyme to generate a catalytically improved and controllable ATP synthase which in turn will help in building a superior nanomotor. For comparison, several other biological nanomotors will be described as well as their applications for nanotechnology.
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subjects Adenosine triphosphatase
Adenosine triphosphate
Animals
ATP
ATP Synthetase Complexes - antagonists & inhibitors
ATP Synthetase Complexes - chemistry
ATP Synthetase Complexes - metabolism
Bacteria
Bacterial infections
Catalysis
Deoxyribonucleic acid
DNA
DNA polymerase
Dyneins - metabolism
E coli
Enzymes
Flagella - metabolism
Health aspects
Humans
Kinesin - metabolism
Laboratories
Medical research
Medicine, Experimental
Methods
Myosins - metabolism
Nanomedicine
Nanotechnology
Proteins
Review
RNA polymerase
title ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine
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