Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AUR...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-04, Vol.26 (7), p.1981
Main Authors: Borah, Naheed Arfin, Reddy, Mamatha M
Format: Article
Language:English
Subjects:
AURKB inhibitors
AURKB regulation
Aurora kinase
aurora kinase B (AURKB)
Cancer
Cell cycle
Cell division
Chromosomes
combination therapy
Deregulation
Drug resistance
Gene expression
Inhibitors
Kinases
Leukemia
Medical prognosis
Metastases
Phosphorylation
Protein kinase
Protein-serine/threonine kinase
Proteins
Review
Therapeutic targets
therapy related drug resistance
Tumorigenesis
Tumors
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Summary:Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and drug resistance. AURKB has emerged as an attractive drug target leading to the development of small molecule inhibitors. This review summarizes recent findings pertaining to the role of AURKB in tumor development, therapy related drug resistance, and its inhibition as a potential therapeutic strategy for cancer. We discuss AURKB inhibitors that are in preclinical and clinical development and combination studies of AURKB inhibition with other therapeutic strategies.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26071981