XMEA: A New Hybrid Diamond Multielectrode Array for the In Situ Assessment of the Radiation Dose Enhancement by Nanoparticles

This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-crystal diamond divided into four quadrants for X-...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2024-04, Vol.24 (8), p.2409
Main Authors: Nicolucci, Patricia, Gambaro, Guilherme, Araujo Silva, Kyssylla Monnyelle, Souza Lima, Iara, Baffa, Oswaldo, Pasquarelli, Alberto
Format: Article
Language:English
Subjects:
Analysis
Aqueous solutions
Atoms & subatomic particles
Charged particles
Diamond - chemistry
diamond detector
Dosimetry
Electric fields
Electrodes
Electrons
Gold
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Monte Carlo method
Monte Carlo simulation
multielectrode array (MEA)
Nanoparticles
Nanoparticles - chemistry
Platinum - chemistry
Polyvinyl alcohol
Radiation
Radiation Dosage
radiation dose enhancement
Radiation therapy
Radiotherapy
Sensors
Silicon wafers
Silver
Silver - chemistry
Single crystals
Software
Spectrum analysis
Tissues
X-Rays
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Summary:This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-crystal diamond divided into four quadrants for X-ray dosimetry. DEF was assessed in water solutions with up to a 1000 µg/mL concentration of silver, platinum, and gold nanoparticles. The X-ray detectors showed a linear response to radiation dose (r ≥ 0.9999). Overall, platinum and gold nanoparticles produced a dose enhancement in the medium (maximum of 1.9 and 3.1, respectively), while silver nanoparticles produced a shielding effect (maximum of 37%), lowering the dose in the medium. This work shows that the novel MEA can be a useful tool in the quantitative assessment of radiation dose enhancement due to nanoparticles. Together with its suitability for cells' exocytosis studies, it proves to be a highly versatile device for several applications.
ISSN:1424-8220
1424-8220
DOI:10.3390/s24082409