Gold nanoparticles and near-infrared light as a new tool to enhance tissue regeneration

Controlled temperature elevation within biological tissues, known as hyperthermia, holds promise as a therapeutic treatment. Its efficacy depends on several factors including timing, pulsing, and repetition. Recent research indicates the potential of heat-based therapies not only for cancer treatmen...

Full description

Saved in:
Bibliographic Details
Published in:EPJ Web of conferences 2024, Vol.309, p.4009
Main Authors: Dell’Aversano, Natalia, Amenta, Maria Laura, Rippa, Massimo, Moros, Maria, Tino, Angela, Tortiglione, Claudia, Marchesano, Valentina
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Controlled temperature elevation within biological tissues, known as hyperthermia, holds promise as a therapeutic treatment. Its efficacy depends on several factors including timing, pulsing, and repetition. Recent research indicates the potential of heat-based therapies not only for cancer treatment but also in tissue regeneration. The usage of photothermal agents, such as gold nanoparticles, enables precise spatio-temporal heat generation, known as photothermal therapy (PTT). Hydra vulgaris , with their unique regenerative capabilities, serve as valuable models for exploring the effects of nanoparticles on tissue regeneration. AuNPs thanks to their plasmonic properties can induce physiological responses in the animals under near-infrared (NIR) irradiation, ranging from cell ablation to programmed cell death or thermotolerance. By tuning the NIR irradiation and the AuNPs dose, the capability of treated polyps to regenerate the missing heads under photostimulation will be dissected, at whole animal, cellular and molecular levels and compared to exposure to external macroscopic heat sources.
ISSN:2100-014X
2100-014X
DOI:10.1051/epjconf/202430904009