Shaping the next steps of research on frailty: challenges and opportunities

Evidence of its deleterious impact on health has been consistent, including a two-fold increase in risks of falls and fractures, physical impairment, loss of independence in activities of daily living, hospitalization, and death [15]. [...]longitudinal studies revealed exponential trajectory of frai...

Full description

Saved in:
Bibliographic Details
Published in:BMC geriatrics 2021-07, Vol.21 (1), p.432-432, Article 432
Main Authors: Aprahamian, Ivan, Xue, Qian-Li
Format: Article
Language:English
Subjects:
Activities of daily living
Aged
Aging
Bioengineering
Biomarkers
Clinical medicine
Comorbidity
Disease
Drug development
Frail Elderly
Frailty
Frailty - diagnosis
Frailty - epidemiology
Frailty - therapy
Geriatric Assessment
Geriatrics
Humans
Hypotheses
Intervention
Older people
Physiology
Quality of life
Risk assessment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence of its deleterious impact on health has been consistent, including a two-fold increase in risks of falls and fractures, physical impairment, loss of independence in activities of daily living, hospitalization, and death [15]. [...]longitudinal studies revealed exponential trajectory of frailty progression with aging in both sexes and in both frailty models [13], and in the case of physical frailty, a recent study concluded that meeting all five PF criteria signifies “a critical transition toward a point of no return beyond which the process becomes irreversible and death becomes imminent” [16]. [...]there remains an urgent need to balance between the continuing quests for development of therapeutics targeting frailty in its own right, and improving the quality of life of frail individuals by modernizing healthcare delivery systems. [...]the increasing use of omics-based technologies in frailty research represents a new frontier in a quest to identify novel biological molecules and mechanisms responsible for the generalized physiological dysregulation associated with frailty [25]. [...]heterogeneity in frailty assessment and causes of frailty (e.g., secondary vs. primary frailty) impairs our ability to discern signal amidst noise (or different signals depending on the cause of frailty) and conduct cross-study comparisons. [...]omics studies built on specific hypothesis may be a more fruitful approach.
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-021-02370-z