Nitrogen Doped Carbon-Dot Embedded Poly(lactic acid-co-glycolic acid) Composite Films for Potential Use in Food Packing Industry and Wound Dressing

Here, nitrogen-doped carbon dots (N-doped CDs) were synthesized by the hydrothermal method embedded within poly(lactic acid-co-glycolic acid) ((PLGA)) films at different amounts. The N-doped CDs (or CD) that possess fluorescence properties also have antimicrobial properties against S. aureus and E....

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Bibliographic Details
Published in:Journal of composites science 2022-09, Vol.6 (9), p.260
Main Authors: Sahiner, Mehtap, Ari, Betul, Ram, Manoj K., Sahiner, Nurettin
Format: Article
Language:English
Subjects:
Acids
Antiinfectives and antibacterials
antimicrobial film
Biocompatibility
Blood
Carbon
carbon dot
Carbon dots
Clotting
Drug delivery systems
E coli
FDA approval
Fluorescence
fluorescence film composite
Food packaging
food packing
Fourier transforms
Glycolic acid
hemocompatible
Hemolysis
Lactic acid
Microorganisms
Nanoparticles
Nitrogen
Physiology
Polyvinyl alcohol
Spectrum analysis
wound dressing
Wound healing
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Summary:Here, nitrogen-doped carbon dots (N-doped CDs) were synthesized by the hydrothermal method embedded within poly(lactic acid-co-glycolic acid) ((PLGA)) films at different amounts. The N-doped CDs (or CD) that possess fluorescence properties also have antimicrobial properties against S. aureus and E. coli microorganisms, determined by the disc diffusion method with 19 ± 2 and 18 ± 1 mm zone diameters, respectively. The CD embedded PLGA films (CD@PLGA) with different CD contents revealed an increased fluorescence intensity with the increased amount of CD. Moreover, the antibacterial potency of 50% CD containing PLGA (50-CD@PLGA) films (by weight) against S. aureus and E. coli microorganisms was examined and the zone diameters were found to be 14 ± 1 and 13 ± 1 mm, respectively. In addition, CD release studies from different amounts of CD (2.5–50 by weight) containing composite films showed that 50-CD@PLGA film released 127 ± 16 mg/g CD dots, which is 38 ± 5% of the embedded CDs in about 12 days, suggesting their potential application in food packing and wound dressing. Moreover, all CD@PLGA films were found to be blood compatible via hemolysis and blood clotting index tests with 90% blood clotting indices regardless of their CD content.
ISSN:2504-477X
2504-477X
DOI:10.3390/jcs6090260