Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience

Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and ident...

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Published in:Diagnostics (Basel) 2023-06, Vol.13 (12), p.2093
Main Authors: Terzi, Silvia, Trentin, Federica, Griffoni, Cristiana, Carretta, Elisa, Bandiera, Stefano, Ferrari, Cristina, Vita, Fabio, Righi, Alberto, Maioli, Margherita, De Biase, Dario, Monetta, Annalisa, Barbanti Brodano, Giovanni, Evangelisti, Gisberto, Girolami, Marco, Pipola, Valerio, Gambarotti, Marco, Gasbarrini, Alessandro
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Care and treatment
Development and progression
Fractures
Health aspects
Kinases
Localization
Lung cancer
Medical prognosis
Metastasis
Mutation
non-small-cell lung cancer
Oncology, Experimental
Patients
quality of life
Radiation therapy
Spinal cord
spinal metastases
spine surgery
Surgery
survival
Survival analysis
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Summary:Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13122093