Connecting the dots – A systematic review on coherence analysis in dystonia

• Published in: Neurobiology of disease 2024-10, Vol.200, p.106616, Article 106616
• Main Authors: Lagerweij, S.A.J.E.A., Smit, M., Centen, L.M., van Dijk, J.M.C., van Egmond, M.E., Elting, J.W., Tijssen, M.A.J.
• Format: Article
• Language: English
• Subjects: Coherence; DBS; Dystonia; Neurophysiology
• ISSN: 0969-9961; 1095-953X; 1095-953X
• DOI: 10.1016/j.nbd.2024.106616

Increased 4–12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia. Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG). The aim of this study is to perform a systematic review on the use of coherence analysis for clinical assessment and treatment of dystonia. A systematic review was performed on a search in Embase and PubMed on June 28th, 2023. All studies incorporating coherence analysis and an adult dystonia cohort were included. Three authors evaluated the eligibility of the articles. Quality was assessed using the QUADAS-2 checklist. A total of 41 articles were included, with data of 395 adult dystonia patients. In the selected records, six different types of coherence were investigated: corticocortical, corticopallidal, corticomuscular, pallidopallidal, pallidomuscular, and intermuscular coherence. Various types of 4–12 coherence were found to be increased in all dystonia subtypes. There is increased 4–12 Hz coherence found between the cortex, basal ganglia, and affected muscles in all dystonia subtypes. However, the relationship between 4-12 Hz coherence and the dystonic clinical state has not been established. DBS treatment leads to a reduction of 4–12 Hz coherence. In combination with the results of this review, the 4–12 Hz frequency band can be used as a promising phenomenon for the development of a biomarker.