Spotlight on reticular pseudodrusen

Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen....

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2017-01, Vol.11, p.1707-1718
Main Authors: Rabiolo, Alessandro, Sacconi, Riccardo, Cicinelli, Maria Vittoria, Querques, Lea, Bandello, Francesco, Querques, Giuseppe
Format: Article
Language:English
Subjects:
Age
age-related macular degeneration
Atrophy
Cardiovascular disease
Care and treatment
choroidal neovascularization
Diagnosis
Genotype & phenotype
geographic atrophy
Macular degeneration
Medical imaging
Mortality
Neovascularization
Ophthalmology
Physiological aspects
Population
reticular drusen
reticular macular degeneration
reticular macular disease
reticular pseudodrusen
Retina
Review
Risk factors
subretinal drusenoid deposit
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Summary:Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD. RPD identification is not straightforward at fundus examination, and their identification should employ at least 2 different imaging modalities. In this narrative review, we embrace all aspects of RPD, including history, epidemiology, histology, imaging, functional test, natural history and therapy.
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S130165