Function of Dental Follicle Progenitor/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications

Dental follicle progenitor/stem cells (DFPCs) are a group of dental mesenchyme stem cells that lie in the dental follicle and play a critical role in tooth development and maintaining function. Originating from neural crest, DFPCs harbor a multipotential differentiation capacity. More importantly, t...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-07, Vol.11 (7), p.997
Main Authors: Bi, Ruiye, Lyu, Ping, Song, Yiming, Li, Peiran, Song, Dongzhe, Cui, Chen, Fan, Yi
Format: Article
Language:English
Subjects:
Alveolar bone
Bone growth
Bone healing
Cell self-renewal
differentiation
Enamel
Follicles
Gene expression
Growth factors
Immunomodulation
immunoregulation
Ligands
Mesenchyme
Microenvironments
Mineralization
Neural crest
Periodontium
Phosphatase
Proteins
Regenerative medicine
Review
scaffold
stem cell therapy
Stem cells
Tissue engineering
tissue regeneration
tooth development
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Summary:Dental follicle progenitor/stem cells (DFPCs) are a group of dental mesenchyme stem cells that lie in the dental follicle and play a critical role in tooth development and maintaining function. Originating from neural crest, DFPCs harbor a multipotential differentiation capacity. More importantly, they have superiorities, including the easy accessibility and abundant sources, active self-renewal ability and noncontroversial sources compared with other stem cells, making them an attractive candidate in the field of tissue engineering. Recent advances highlight the excellent properties of DFPCs in regeneration of orofacial tissues, including alveolar bone repair, periodontium regeneration and bio-root complex formation. Furthermore, they play a unique role in maintaining a favorable microenvironment for stem cells, immunomodulation and nervous related tissue regeneration. This review is intended to summarize the current knowledge of DFPCs, including their stem cell properties, physiological functions and clinical application potential. A deep understanding of DFPCs can thus inspire novel perspectives in regenerative medicine in the future.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11070997