Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis

• Published in: Clinical interventions in aging 2021-01, Vol.16, p.1013-1022
• Main Authors: Luo, Yunfang, Yu, Fang, Feng, Xianjing, Liao, Di, Ying, Yuanlin, Li, Xi, Huang, Qin, Liu, Zeyu, Wei, Minping, Zhao, Tingting, Zhang, Lin, Tu, Ruxin, Xia, Jian
• Format: Article
• Language: English
• Subjects: Age; Aged; Angina pectoris; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Atherosclerosis; Biological markers; Biomarkers; Biomarkers - blood; Blood pressure; Brain Ischemia - metabolism; C-Reactive Protein - metabolism; Cardiovascular disease; Case-Control Studies; Cerebrovascular disease; Coronary vessels; Development and progression; Diabetes; Diagnosis; Fibrinogen - metabolism; Genetic aspects; Glucose; Health aspects; Health risk assessment; Homocysteine; Humans; Hypertension; Identification and classification; Intracranial Arteriosclerosis - complications; Intracranial Arteriosclerosis - metabolism; Ischemia; ischemic stroke; Laboratories; Lipoproteins; Male; Males; Medical imaging; Middle Aged; molecular biomarkers; Older people; Original Research; Patients; Risk Factors; Smoking; Stroke; Stroke - complications; Stroke - metabolism; symptomatic intracranial atherosclerosis; Transient ischemic attack; Triglycerides - blood; Values
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S309945

Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention. We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤60 years old and late-onset sICAS group as age >60 years old. We collected and compared the demographic data and laboratory results of each group. A bivariate logistic regression model was applied to evaluate the independent molecular biomarkers of early-onset sICAS. A total of 1007 subjects with sICAS were enrolled in this study, comprising 519 patients in the early-onset sICAS group and 488 patients in the late-onset sICAS group. Bivariate logistic regression analysis demonstrated an increased level of white blood cell, platelet, albumin globulin ratio, free triiodothyronine, and a decreased level of total bile acid, urea nitrogen, high-density lipoprotein, homocysteine, and fibrinogen in the early-onset sICAS group when compared to the late-onset group. Our study showed the relevance between early sICAS and circulating levels of different molecular biomarkers. Detection of these related molecular biomarkers may provide a simple way for early sICAS preventions in the future.